An application of inhibited redox reactions for quantitative analysis of fluoride ions in selected pharmaceutical preparations.

Pharmaceutical preparations containing sodium fluoride as an active substance have been examined. To do it, a procedure developed previously that uses the inhibition of redox reaction in the system under investigation was employed. For determination purposes, visible range spectrophotometry and redoxometric titration enabling indirect quantitative determination of fluoride ions in preparations under examination have been applied.

Validation of capillary gas chromatographic method for determination of bilobalide and ginkgolides A, B, C in Ginkgo biloba dry and liquid extracts.

A method for identification and quantitative determination of ginkgolides A, B, and C and bilobalide in liquid and dry extracts of Ginkgo biloba extracts has been developed. Determinations made by employing capillary gas chromatography technique with FID detection were preceded by derivatization using BSTFA with TMCS addition at 120 degrees C. Cholesterol was used as an internal standard.

Spectrophotometric determination of Pb(II), Fe(III) and Bi(III) in complexes with 1,2-diaminocyclohexane-N,N,N',N'-tetraacetic acid (DACT).

A UV spectrophotometric method was developed for simultaneous determination of ions: Pb(II), Fe(III) and Bi(III) in complexes with DACT. Zero-order and derivative spectra were used for the determinations. Under the established experimental conditions the described method furnished reliable results with low limit of detection (from 0.

Determination of metoprolol and hydrochlorothiazide by derivative spectrophotometric method in pharmaceutical preparations.

A procedure for simultaneous determination of metoprolol and hydrochlorothiazide in tablets by employing derivative spectrophotometry, "zero-crossing" method was developed. The third order derivative absorption spectra at lambda approximately 281 nm were used for metoprolol and the first order derivative spectra at lambda approximately 282 nm were used for hydrochlorothiazide. No interferences were found between both determined constituents and those of matrix.

Application of copper (II) in spectrophotometric determination of some drugs of aliphatic amine nature.

Anhydrous copper(II) acetate was applied to spectrophotometric determination of amitriptilline, doxepin and lignocaine in acetone solutions. The developed method was employed for determining these substances in pharmaceutical preparations. The obtained results has indicated both high precision and accuracy of the method.

Application of derivative spectrophotometry to simultaneous determination of indomethacin and 5-methoxy-2-methyl-3-indoleacetic acid in metindol injections.

Derivative spectrophotometry was employed to develop a rapid and accurate method for simultaneous determination of indomethacin and 5-methoxy-2-methyl-3-indoleacetic acid as its possible impurity in Metindol injections. At the selected wavelengths, 233.04 and 284.

Direct determination of Pb(II) and Cd(II) ions as impurities in some homeopathic drugs by using stripping voltammetry.

The conditions for identification and quantilication of Pb(II) and Cd(II) ions as impurities in homeopathic preparations by stripping voltammetry were established. The tests proved that the method was of high selectivity. The detection limits were 0.

Direct separation, identification and quantification of epimers 22R and 22S of budesonide by capillary gas chromatography on a short analytical column with Rtx-5 stationary phase.

The conditions for separation, identification and quantitative determination of epimers 22R and 22S of budesonide by capillary gas chromatography (GC) with FID detection and two various sample injection methods, namely split-splitless and cool on-column, were established. In analysis helium as carrier gas and Rtx-5 capillary column of 7 m in length along with stationary phase Crossbond 5% diphenyl-95% dimethyl polysiloxane were used. The individual epimers were identified under specified conditions by using standard samples of different declared concentration of each epimer under investigation: (1) 51.

Validation of a method for simultaneous determination of menthol and methyl salicylate in pharmaceuticals by capillary gas chromatography with cool on-column injection.

The conditions for the identification and quantitative determination of menthol and methyl salicylate in ointment Balsamum Mentholi Compositum on a hydrocarbon-ester base (vaseline-lanolin), have been established by using capillary gas chromatography with cool on-column injection and flame ionization detection (FID). The good separation of menthol (tR = 7.2 min), methyl salicylate (tR = 8.