Robot-assistant for MRI-guided liver ablation: A pilot study.

Purpose: Percutaneous ablation under MRI-guidance allows treating otherwise inoperable liver tumors locally using a catheter probe. However, manually placing the probe is an error-prone and time consuming task that requires a considerable amount of training. The aim of this paper was to present a pneumatically actuated robotic instrument that can assist clinicians in MRI-guided percutaneous intervention of the liver and to assess its functionality in a clinical setting.

Optothermal profile of an ablation catheter with integrated microcoil for MR-thermometry during Nd:YAG laser interstitial thermal therapies of the liver—an in-vitro experimental and theoretical study.

Purpose: Flexible microcoils integrated with ablation catheters can improve the temperature accuracy during local MR-thermometry in Nd:YAG laser interstitial thermal therapies. Here, the authors are concerned with obtaining a preliminary confirmation of the clinical utility of the modified catheter. They investigate whether the thin-film substrate and copper tracks of the printed coil inductor affect the symmetry of the thermal profile, and hence of the lesion produced.

Renal artery stenosis: comparative assessment by unenhanced renal artery MRA versus contrast-enhanced MRA.

Objectives: To evaluate steady-state free precession (SSFP) non-contrast-enhanced MR angiography (Unenhanced-MRA) versus conventional contrast-enhanced MR angiography (CE-MRA) in the detection of renal artery stenosis (RAS).

Methods: Retrospective analysis of 70 consecutive patients referred for suspected RAS, examined by SSFP Unenhanced-MRA and CE-MRA. Image quality, quality of visible renal arterial segments, presence and grade of RAS were evaluated.

Midfoot and hindfoot bone marrow edema identified by magnetic resonance imaging in feet of subjects with diabetes and neuropathic ulceration is common but of unknown clinical significance.

Objective: We conducted a retrospective cohort study assessing the prevalence and clinical and radiological outcome of remote areas of bone marrow edema on magnetic resonance imaging (MRI) in the feet of subjects with diabetes and neuropathic foot ulceration.

Research Design And Methods: MRIs performed over 6 years looking for osteomyelitis associated with neuropathic lesions were assessed for remote areas of signal change.

Results: Seventy MRI studies were assessed.

Low wall shear stress predicts subsequent development of wall hypertrophy in lower limb bypass grafts.

Background: Venous grafts commonly develop myointimal hyperplasia, which can lead to stenoses and, ultimately, with expression of adhesion molecules, lumenal occlusion. The aim of the present study was to investigate whether wall shear stress measured post-operatively would predict subsequent myointimal hypertrophy in lower limb venous bypass grafts.

Methods: Magnetic resonance imaging and ultrasound were performed in a cohort of patients following lower limb venous bypass graft surgery for peripheral arterial disease at baseline (1-2 weeks) and at follow-up (9-12 months).

Laser ablation of hepatocellular carcinoma--a review.

A wide range of local thermal ablative therapies have been developed in the treatment of non resectable hepatocellular carcinoma (HCC) in the last decade. Laser ablation (LA) and radiofrequency ablation (RFA) are the two most widely used of these. This article provides an up to date overview of the role of laser ablation in the local treatment of HCC.

MR-guided focused ultrasound.

The joining of high-intensity focused ultrasound with high-resolution MR guidance has created a system that can produce tissue destruction deep within solid organs without any invasion. Accurate targeting and thermal mapping are provided by MRI and allow very accurate deposition of energy in tissues that can be altered in response to near real-time thermal imaging produced by MR so that the variation in tissue response that is otherwise observed can be overcome. Current areas of successful application of MR-guided focused ultrasound are described in the treatment of uterine fibroids and other areas of emerging applications in additional solid organs are also discussed.

Magnetic resonance guidance of thermal ablation.

The aim of this study is to describe all aspects of the process of using MR imaging to control thermal ablation procedures and the strengths and weaknesses of the individual thermal ablation modalities in relation to their use in the MR environment. Magnetic resonance thermal sequences, MR scanner configurations, and the different thermal ablation modalities are discussed in the context of how they are commonly used in MR scanners to provide optimal image guidance of therapy. The outcomes of completed research on some of the applications of thermal tissue ablation using MR guidance are described to indicate how these processes may impact patient treatment.

Focused ultrasound treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative technique.

Objective: The purpose of this study was to determine the safety and efficacy of focused ultrasound surgery with magnetic resonance imaging guidance for the noninvasive treatment of uterine leiomyomas.

Study Design: Fifty-five women with clinically significant uterine leiomyomas were treated. Pain and complications were assessed prospectively, and posttreatment magnetic resonance imaging was used to measure the treatment effects.

Feasibility of abdomino-pelvic T1-weighted real-time thermal mapping of laser ablation.

Purpose: To prove the hypothesis that T1-weighted (T1W) thermal mapping is reliable and achievable in magnetic resonance (MR)-guided laser tumor ablation.

Materials And Methods: Near real-time gray and color-scale T1W thermal maps in 111 MR-guided laser thermal ablations (LTA) of liver, kidney, and uterine tumors were studied. After laser fiber placement, near real-time gray and color-scale thermal maps were produced.