Apoptosis induction by 7-chloroquinoline-1,2,3-triazoyl carboxamides in triple negative breast cancer cells.

Breast cancer is a major public health burden in both developed and developing countries and there is still a need to screen new molecules with different modes of actions. The aims of this study were to evaluate the selectivity profile, apoptotic cell death and cell cycle arrest induced by 7-chloroquinoline-1,2,3-triazoyl carboxamides derivatives in hormonal-dependent and hormonal-independent breast cancer cells. Results showed significantly decreased MCF-7 and MDA-MB-231 cells viability in vitro in a dose dependent manner after treatment with 7-chloroquinoline derivatives QTCA-1, QTCA-2 and QTCA-3.

[Prevalence of near vision deficiency and related factors: a population-based study].

The objective of this article was to estimate the prevalence of presbyopia in adults > or = 30 years and explore associated characteristics such as demographic, socioeconomic, and individual variables. A cross-sectional, population-based study was performed with 3,007 adults > or = 30 years in Pelotas, Rio Grande do Sul, Brazil. Near vision acuity was evaluated using the Jaeger table, and other variables were investigated using standardized, pre-coded questionnaires.