Characteristics of patients with somatoform pain disorder.

Background: Patients with somatoform pain experience physical pain that cannot be attributed to any underlying medical or physiological cause, and it is often thought to be related to psychological factors. Health professionals encounter difficulties identifying this specific type of chronic pain, leading to suboptimal treatment strategies. Therefore, we aimed to describe the characteristics of patients with somatoform pain, to support the identification of affected patients.

Influence of magnetic convection on separation efficiency in magnetophoretic microfluidic processes: a combined simulation and experimental study.

This work explores the complex hydrodynamics in magnetophoretic microfluidic processes, focusing on the interplay of forces and particle concentrations. The study employs a combined simulation and experimental approach to investigate the impact of magnetophoresis on magneto-responsive nanoparticles (MNPs) and their environment, including non-magneto-responsive nanoparticles (non-MNPs) in a microfluidic system. Our findings reveal that the motion of MNPs induces a hydrodynamic convective motion of non-MNPs, significantly affecting the separation efficiency and purity of the particles.

The Influence of the Big Five Personality Factors on Mental Health Before and During the COVID-19 Pandemic: A Prospective Study.

The Big Five personality factors (PF) are considered to be predictive of mental health problems, but it is unclear if these factors equally contributed to mental health problems during the COVID-19 pandemic compared to before the pandemic. This prospective study aimed to fill this knowledge gap. For this purpose data was extracted from the population-based LISS-panel.

The effects of potentially traumatic events on the recovery from pre-existing anxiety and depression symptomatology and the risk of PTSD.

Aim: The extent to which recent potentially traumatic events (PTEs) hinder the recovery from pre-existing mental health problems is largely unknown. The same applies to the extent to which non-recovery from pre-existing mental health problems increases the risk of posttraumatic stress disorder (PTSD). The aim of the present study is to gain insight in these effects.

Personality Functioning Improvement during Psychotherapy Is Associated with an Enhanced Capacity for Affect Regulation in Dreams: A Preliminary Study.

Background: Clinical case illustrations of patients with an impairment of personality functioning (IPF) have repeatedly reported that progress during psychotherapy is reflected by alterations in dream content. However, quantitative studies based on samples of psychotherapy patients are scarce. As a core component of both personality functioning and contemporary psychodynamic dream theory, the construct of affect regulation is of specific significance in this context.

Millifluidic magnetophoresis-based chip for age-specific fractionation: evaluating the impact of age on metabolomics and gene expression in yeast.

A novel millifluidic process introduces age-based fractionation of var. yeast culture through magnetophoresis. yeast is a model organism for aging research used in various industries.

Correction: Responses to the Islamic headscarf in everyday interactions depend on sex and locale: A field experiment in the metros of Brussels, Paris, and Vienna on helping and involvement behaviors.

[This corrects the article DOI: 10.1371/journal.pone.

The Demographic-Wealth model for cliodynamics.

Cliodynamics is a still a relatively new research area with the purpose of investigating and modelling historical processes. One of its first important mathematical models was proposed by Turchin and called "Demographic-Fiscal Model" (DFM). This DFM was one of the first and is one of a few models that link population with state dynamics.

Mediators of Outcome in Trauma-Focused Psychotherapy with Youth: A Systematic Review.

This article aimed to provide a systematic narrative synthesis of existing studies on the mediators of change in psychotherapy with adolescents (10-19 years) and transition age youth (TAY) (20-29 years) who have experienced trauma-related symptoms or posttraumatic disorder. Additionally, we were interested in identifying psychotherapy-, trauma type-, and clients' age- and gender-specific mediators of treatment outcome. Following the preferred reporting items for systematic reviews and meta-analyses, a total of 3,723 studies published in PubMed and PsycINFO databases were screened against inclusion criteria, revealing 15 eligible studies.

Patients' perception of side effects in cognitive-behavior, psychodynamic, and psychoanalytic outpatient psychotherapy.

Objective: To assess and compare the frequency of psychotherapeutic side effects in different psychotherapeutic approaches.

Method: Side effects were assessed across 17 domains through structured interviews with 45 outpatients in cognitive-behavior, psychodynamic, and psychoanalytic psychotherapy.

Results: Almost every patient (95.

Dispersion-corrected r2SCAN based double-hybrid functionals.

The regularized and restored semi-local meta-generalized gradient approximation (meta-GGA) exchange-correlation functional r2SCAN [Furness et al., J. Phys.

Characterization of Fluorescent Dyes Frequently Used for Bioimaging: Photophysics and Photocatalytical Reactions with Proteins.

Derivatives of the rhodamine-based dye 5-TAMRA (5-carboxy-tetramethylrhodamine) and the indocarbocyanine-type Cy3B (cyclized derivative of the cyanine dye Cy3), both representing important fluorophores frequently used for the labeling of biomolecules (proteins, nucleic acids) and bioactive compounds, such as receptor ligands, were photophysically investigated in aqueous solution, i.e., in neat phosphate-buffered saline (PBS) and in PBS supplemented with 1 wt % bovine serum albumin (BSA).

Investigating the Integration of Nonwoven Carbon Fibers for Mechanical Enhancement in Compression Molded Fiber-Reinforced Polymer Bipolar Plates.

The demand for polymer composite solutions in bipolar plates for polymer electrolyte membrane fuel cells (PEMFCs) has risen due to advantages over metal plates such as longer lifetime, weight reduction, corrosion resistance, flexible manufacturing, freedom of design, and cost-effectiveness. The challenge with polymer composites is achieving both sufficient electrical conductivity and mechanical stability with high filler content. A carbon fiber fleece as reinforcement in a graphite-filled polypropylene (PP) matrix was investigated for use as bipolar plate material with increased mechanical and sufficient conductive properties.

Human talkers change their voices to elicit specific trait percepts.

The voice is a variable and dynamic social tool with functional relevance for self-presentation, for example, during a job interview or courtship. Talkers adjust their voices flexibly to their situational or social environment. Here, we investigated how effectively intentional voice modulations can evoke trait impressions in listeners (Experiment 1), whether these trait impressions are recognizable (Experiment 2), and whether they meaningfully influence social interactions (Experiment 3).

Quantification methods of determining brewer's and pharmaceutical yeast cell viability: accuracy and impact of nanoparticles.

For industrial processes, a fast, precise, and reliable method of determining the physiological state of yeast cells, especially viability, is essential. However, an increasing number of processes use magnetic nanoparticles (MNPs) for yeast cell manipulation, but their impact on yeast cell viability and the assay itself is unclear. This study tested the viability of Saccharomyces pastorianus ssp.

Studying the impact of cell age on the yeast growth behaviour of Saccharomyces pastorianus var. carlsbergensis by magnetic separation.

Despite the fact that yeast is a widely used microorganism in the food, beverage, and pharmaceutical industries, the impact of viability and age distribution on cultivation performance has yet to be fully understood. For a detailed analysis of fermentation performance and physiological state, we introduced a method of magnetic batch separation to isolate daughter and mother cells from a heterogeneous culture. By binding functionalised iron oxide nanoparticles, it is possible to separate the chitin-enriched bud scars by way of a linker protein.

To what extent do post-traumatic mental health and other problems reflect pre-existing problems? Findings from the prospective comparative population-based VICTIMS-study.

Background: Findings from prospective studies question the assumption that mental health problems observed in traumatized adults mainly reflect the effects of potentially traumatic events.

Aims: Aim of the present comparative prospective study is to clarify the extent to which victims of potentially traumatic events with mental health, social, financial, and/or legal problems, already suffered from such problems before these events.

Method: Data was extracted from three surveys of the prospective VICTIMS-study (T1 = 2018, T2 = 2019, T3 = 2020), conducted with the population-based longitudinal LISS-panel.

Electrostatic anti-CD33-antibody-protamine nanocarriers as platform for a targeted treatment of acute myeloid leukemia.

Background: Acute myeloid leukemia (AML) is a fatal clonal hematopoietic malignancy, which results from the accumulation of several genetic aberrations in myeloid progenitor cells, with a worldwide 5-year survival prognosis of about 30%. Therefore, the development of more effective therapeutics with novel mode of action is urgently demanded. One common mutated gene in the AML is the DNA-methyltransferase DNMT3A whose function in the development and maintenance of AML is still unclear.

Guilt is effectively induced by a written auto-biographical essay but not reduced by experimental pain.

Introduction: The aim of the present study was (1) to validate the method of guilt-induction by means of a written auto-biographical essay and (2) to test whether experimental pain is apt to alleviate the mental burden of guilt, a concept receiving support from both empirical research and clinical observation.

Methods: Three independent groups of healthy male participants were recruited. Group allocation was not randomized but within group pain/sham administration was counterbalanced over the two test-days.

Peptide adsorption on silica surfaces: Simulation and experimental insights.

The understanding of interactions between proteins with silica surface is crucial for a wide range of different applications: from medical devices, drug delivery and bioelectronics to biotechnology and downstream processing. We show the application of EISM (Effective Implicit Surface Model) for discovering the set of peptide interactions with silica surface. The EISM is employed for a high-speed computational screening of peptides to model the binding affinity of small peptides to silica surfaces.

Biaxial Elongation Behavior in Partially Molted State of Two-Layer Sheets Containing Postconsumer Material.

Due to the lack of raw material and forced by political demand, an increasing percentage of postconsumer materials (PCR) shall be used in all processing methods in polymer technology. Thermoforming, as one of the oldest polymer-processing methods, has special requirements regarding the melt stability at high temperatures. Low melt stability affects the thermoforming in a negative manner, as the low stiffness leads the sheet to sag during the heating phase.

Synthetic Approach to the Natural -Nitrosohydroxylamino Tetramic Acid JBIR-141.

An analogue of the metabolite JBIR-141, featuring a delicate -nitrosohydroxylamine, a 3-acyltetramic acid, and an oxazoline, was synthesized by a convergent strategy from l-alanine, l-threonine, and l-glutamic acid. Key steps were the cyclization of an Ala-Thr derivative to give the oxazoline, a Dieckmann condensation affording the 3-acyltetramic acid, and the -nitrosation of a hydroxylamino derivative of glutamic acid. An adequate protecting group strategy was established for coupling the three building blocks.

Two Layer Sheets for Processing Post-Consumer Materials.

An increasing percentage of post-consumer materials (PCR) is becoming more and more important in all processing methods in polymer technology, also due to the lack of raw materials and political demands. Very special requirements are placed on material properties such as viscosities in extrusion. Low viscosities and the presence of particles affect extrusion in a negative manner.