Convergent QSAR Models for the Prediction of Cruzain Inhibitors.

Chagas disease is a parasitosis caused by . Cruzain, the major cysteine protease from , is an excellent therapeutic target in the search for antichagasic drugs. It is important in the role of cell invasion, replication, differentiation, and metabolism of the parasite.

Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets.

Introduction: Chagas disease (CD) imposes social and economic burdens, yet the available treatments have limited efficacy in the disease's chronic phase and cause serious adverse effects. To address this challenge, target-based approaches are a possible strategy to develop new, safe, and active treatments for both phases of the disease.

Areas Covered: This review delves into target-based approaches applied to CD drug discovery, emphasizing the studies from the last five years.

Ligand and structure-based virtual screening applied to the SARS-CoV-2 main protease: an repurposing study.

The identification of drugs for the coronavirus disease-19 pandemic remains urgent. In this manner, drug repurposing is a suitable strategy, saving resources and time normally spent during regular drug discovery frameworks. Essential for viral replication, the main protease has been explored as a promising target for the drug discovery process.