Publications by authors named "Witold P Kot"
The development of necrotizing enterocolitis (NEC), a life-threatening inflammatory bowel disease affecting preterm infants, is connected with gut microbiota dysbiosis. Using preterm piglets as a model for preterm infants we recently showed that fecal microbiota transplantation (FMT) from healthy suckling piglet donors to newborn preterm piglets decreased the NEC risk. However, in a follow-up study using donor stool from piglets recruited from another farm, this finding could not be replicated.
View Article and Find Full Text PDFBacterial vaginosis (BV) is characterized by a reduction in spp. abundance and increased abundance of facultative anaerobes, such as spp. BV aetiology is not fully understood; however, bacteriophages could play a pivotal role in the perturbation of the vaginal bacterial community.
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- A transcriptome study on Sulfolobus islandicus REY15A showed that the organism acquired CRISPR spacers from the virus STSV2 while growing in different types of media over six days.
- The acquisition of spacers led to a slowdown in host growth, changes in the activity of various CRISPR-Cas modules, and fluctuating viral copy numbers, with notable differences between the media types.
- Additionally, the study found that certain proteins crucial for cell cycle progression had reduced transcript levels, while others related to DNA management and transposases showed increased or stable expression, suggesting a complex regulatory network involving antisense RNAs and coordination between CRISPR-Cas system modules.