Publications by authors named "Wisseler H"
Eur J Immunogenet
February 1999
Article Synopsis
- The study analyzed the influence of HLA-DRB1 and -DQB1 alleles on disease progression in 201 rheumatoid arthritis (RA) patients, identifying a significant association with the HLA class II alleles sharing the (Q)R/KRAA amino acid motif.
- Among RA patients, 79% had the (Q)R/KRAA motif, with homozygosity significantly linked to increased severity of rheumatoid factor positivity and disease outcomes measured by Larsen Score and Health Assessment Questionnaire.
- However, the genetic predisposition indicated by HLA-DR did not correlate with severe extraarticular disease, suggesting that while HLA-DR is important for RA susceptibility, it may have limited utility in predicting individual disease progression.
