Publications by authors named "Wisse L"

Background: Systemic lupus erythematosus (SLE) often presents with neuropsychiatric (NP) involvement, including cognitive impairment and depression. Past magnetic resonance imaging (MRI) research in SLE patients showed smaller hippocampal volumes but did not investigate other medial temporal lobe (MTL) regions. Our study aims to compare MTL subregional volumes in SLE patients to healthy individuals (HI) and explore MTL subregional volumes in relation to neuropsychiatric SLE (NPSLE) manifestations.

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Background: Prenatal development of autonomic innervation of sinus venosus-related structures might be related to atrial arrhythmias later in life. Most of the pioneering studies providing embryological background are conducted in animal models. To date, a detailed comparison with the human cardiac autonomic nervous system (cANS) is lacking.

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Background: The hippocampus plays a crucial role in memory and is one of the first structures affected by Alzheimer's disease. Postmortem MRI offers a way to quantify the alterations by measuring the atrophy of the inner structures of the hippocampus. Unfortunately, the manual segmentation of hippocampal subregions required to carry out these measures is very time-consuming.

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Inquiries into properties of brain structure and function have progressed due to developments in magnetic resonance imaging (MRI). To sustain progress in investigating and quantifying neuroanatomical details in vivo, the reliability and validity of brain measurements are paramount. Quality control (QC) is a set of procedures for mitigating errors and ensuring the validity and reliability of brain measurements.

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MRI allows brain anatomy to be examined at high resolution and to link pathology measures with morphometric measurements. However, automated segmentation methods for brain mapping in postmortem MRI are not well developed, primarily due to limited availability of labeled datasets, and heterogeneity in scanner hardware and acquisition protocols. In this work, we present a high-resolution dataset of 135 postmortem human brain tissue specimens imaged at 0.

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  • The medial temporal lobe (MTL), thought to be relatively unaffected in early-onset Alzheimer's disease (EOAD), was examined in detail to understand atrophy patterns among different age groups of Alzheimer's patients.
  • The study included participants with memory issues and abnormal brain scans, comparing 41 EOAD individuals under 65 years old with 154 late-onset Alzheimer's (aLOAD) patients aged 70 or older, alongside cognitively healthy controls.
  • Findings revealed that both EOAD and aLOAD groups had smaller MTL regions compared to controls, with specific differences in brain structure and pathology but no significant differences in tau pathology levels between the two Alzheimer's groups.
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  • The paper reviews the introduction of high-resolution T2-weighted MRI scans to the Alzheimer's Disease Neuroimaging Initiative (ADNI) Phase 3, focusing on the medial temporal lobe (MTL) subregions and hippocampal areas.
  • It discusses the application of new surface-based analysis techniques to assess neurodegeneration patterns related to Alzheimer's disease (AD), highlighting the correlation with amyloid and tau biomarkers.
  • The study concludes with insights into the future of high-resolution MTL imaging efforts in ADNI Phase 4, emphasizing the relationship between tau pathology and cortical thinning.
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Introduction: We examined the relations of misfolded alpha synuclein (α-synuclein) with Alzheimer's disease (AD) biomarkers in two large independent cohorts.

Methods: We included Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably Two (BioFINDER-2) and Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (n = 2315, cognitively unimpaired, mild cognitive impairment, AD dementia) who had cross-sectional cerebrospinal fluid (CSF) α-synuclein measurement from seed-amplification assay as well as cross-sectional and longitudinal amyloid beta (Aβ) and tau levels (measured in CSF and/or by positron emission tomography). All analyses were adjusted for age, sex, and cognitive status.

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  • The medial temporal lobe (MTL) is crucial for understanding cognitive decline related to neurodegenerative diseases, but the connection between MTL atrophy and specific proteinopathies remains unclear.
  • Researchers developed two deep learning algorithms to quantitatively measure phosphorylated tau (p-tau) and TDP-43 (pTDP-43) pathology in the MTL, focusing on their roles in Alzheimer's disease and LATE.
  • Their study found that quantitative p-tau measures better correlate with structural changes in the MTL compared to semi-quantitative ratings, revealing significant associations with cortical thickness and volume, especially in severe Alzheimer's cases.
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Importance: The lack of an in vivo measure for α-synuclein (α-syn) pathology until recently has limited thorough characterization of its brain atrophy pattern, especially during early disease stages.

Objective: To assess the association of state-of-the-art cerebrospinal fluid (CSF) seed amplification assays (SAA) α-syn positivity (SAA α-syn+) with magnetic resonance imaging (MRI) structural measures, across the continuum from clinically unimpaired (CU) to cognitively impaired (CI) individuals, in 3 independent cohorts, and separately in CU and CI individuals, the latter reflecting a memory clinic population.

Design, Setting, And Participants: Cross-sectional data were used from the Swedish BioFINDER-2 study (inclusion, 2017-2023) as the discovery cohort and the Swedish BioFINDER-1 study (inclusion, 2007-2015) and Alzheimer's Disease Neuroimaging Initiative (ADNI; inclusion 2005-2022) as replication cohorts.

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The sharing of human neuroimaging data has great potential to accelerate the development of imaging biomarkers in neurological and psychiatric disorders; however, major obstacles remain in terms of how and why to share data in the Open Science context. In this Health Policy by the European Cluster for Imaging Biomarkers, we outline the current main opportunities and challenges based on the results of an online survey disseminated among senior scientists in the field. Although the scientific community fully recognises the importance of data sharing, technical, legal, and motivational aspects often prevent active adoption.

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  • Current understanding of tau neurofibrillary tangles (NFTs) in Alzheimer's Disease is hindered by other non-AD pathologies and limitations of conventional two-dimensional histological methods.
  • The study combines ex vivo MRI and serial histological imaging from 25 human medial temporal lobe specimens to create a high-resolution 3-D atlas that maps the distribution of NFT burden.
  • Findings reveal a gradient in NFT distribution from anterior to posterior in the medial temporal lobe, with highest concentrations in specific regions, suggesting certain areas may serve as early biomarkers for neurodegeneration in Alzheimer's Disease.
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Background: Volumetry of subregions in the medial temporal lobe (MTL) computed from automatic segmentation in MRI can track neurodegeneration in Alzheimer's disease. However, image quality may vary in MRI. Poor quality MR images can lead to unreliable segmentation of MTL subregions.

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Background: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfield volumes and drivers of atrophy in amnestic EOAD is lacking.

Methods: BioFINDER-2 participants with memory impairment, abnormal amyloid-β status and tau-PET were included.

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(1) Mesenchymal stem cells (MSCs) are a valuable cell model to study the bone pathology of Osteogenesis Imperfecta (OI), a rare genetic collagen-related disorder characterized by bone fragility and skeletal dysplasia. We aimed to generate a novel OI induced mesenchymal stem cell (iMSC) model from induced pluripotent stem cells (iPSCs) derived from human dermal fibroblasts. For the first time, OI iMSCs generation was based on an intermediate neural crest cell (iNCC) stage.

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  • The medial temporal lobe (MTL) cortex, essential for memory and vulnerable to diseases like Alzheimer's, consists of various subregions with distinct functions and structures.
  • This study compares the cytoarchitectonic definitions of specific areas within the MTL cortex provided by four different neuroanatomists to assess overlapping and differing delineations among them.
  • Findings revealed more consensus on the entorhinal cortex and Brodmann area 35, while there was less agreement on Brodmann area 36 and the parahippocampal cortex, particularly in transitional zones where defining features are not as clear.
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  • Scientists noticed a new type of inflammation in the hand tendons of people with rheumatoid arthritis and those at risk, which might happen before arthritis symptoms show up.
  • They ran an MRI study on adults with joint pain and healthy people to see how often this tendon inflammation occurs and how it relates to other joint problems.
  • The study included 667 patients and helped researchers understand if tendon inflammation could be an early sign of rheumatoid arthritis.
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Background And Objective: The heart is under strict regulation of the autonomic nervous system, during which, in a healthy state, the effects of sympathetic and parasympathetic branches are balanced. In recent years, there has been increasing interest in pathological remodeling and outgrowth of cardiac autonomic nerves in relation to arrhythmogenesis. However, the small size of the cardiac nerves in relatively large tissues renders research using histological quantification of these nerves extremely challenging and usually relies on quantification of the nerve density in selected regions of interest only.

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The amygdala was highlighted as an early site for neurofibrillary tau tangle pathology in Alzheimer's disease in the seminal 1991 article by Braak and Braak. This knowledge has, however, only received traction recently with advances in imaging and image analysis techniques. Here, we provide a cross-disciplinary overview of pathology and neuroimaging studies on the amygdala.

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Inquiries into properties of brain structure and function have progressed due to developments in magnetic resonance imaging (MRI). To sustain progress in investigating and quantifying neuroanatomical details , the reliability and validity of brain measurements are paramount. Quality control (QC) is a set of procedures for mitigating errors and ensuring the validity and reliability of brain measurements.

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Introduction: Variability in relationship of tau-based neurofibrillary tangles (T) and neurodegeneration (N) in Alzheimer's disease (AD) arises from non-specific nature of N, modulated by non-AD co-pathologies, age-related changes, and resilience factors.

Methods: We used regional T-N residual patterns to partition 184 patients within the Alzheimer's continuum into data-driven groups. These were compared with groups from 159 non-AD (amyloid "negative") patients partitioned using cortical thickness, and groups in 98 patients with ante mortem MRI and post mortem tissue for measuring N and T, respectively.

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Article Synopsis
  • The medial temporal lobe is crucial for episodic memory and is affected differently by aging and Alzheimer's disease, with each condition showing distinct patterns of vulnerability.
  • In preclinical Alzheimer's, there's an increase in functional connectivity in the medial temporal lobe, which declines as the disease progresses into its symptomatic phase.
  • Normal aging leads to decreased connectivity in both the Anterior-Temporal and Posterior-Medial networks, indicating a decline in memory-related brain functions across age.
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  • Abnormal cardiac nerve growth or changes following a heart attack can impact the risk of irregular heartbeats, but there isn't much data on this from medium to long-term studies.
  • This research analyzed heart tissue from pigs three months after a heart attack to understand how nerve patterns are altered, using a new technique for quantifying nerves.
  • Findings showed a mix of nerve growth and loss in heart tissue around the damaged area, with the most variation in nerve density near the heart attack's core, highlighting complex changes in nerve innervation over time.
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  • * The study compares cytoarchitectonic definitions of MTL cortex subregions, specifically focusing on the entorhinal, parahippocampal cortices, and Brodmann areas (BA) 35 and 36, as defined by four different neuroanatomists.
  • * Findings indicate that there is a high agreement on the definitions of the entorhinal cortex and BA35, but less consensus on BA36 and the parahippocampal cortex, especially in transitional areas.
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