Publications by authors named "Wissal Chebil"
Despite the severe impact of uncommon yeast fungal infections and the pressing need for more research on the topic, there are still few studies available on the identification, epidemiology, and susceptibility profile of those pathogens. The aims of the current study were to define the profile of uncommon yeast species at Fattouma Bourguiba University Hospital using phenotypic, molecular, and proteomic methods and to study their antifungal susceptibility profile. Pre-identified uncommon yeast species were collected from 2018 to 2021.
View Article and Find Full Text PDFArticle Synopsis
- The text discusses the role of lipid-dependent basidiomycetes yeasts, specifically concerning their existence as commensals on human and animal skin, and their potential shift to pathogenic forms that trigger various skin disorders.
- It reviews recent literature up to May 2023, focusing on skin disorders linked to these yeasts, their antifungal resistance, and the interactions between the host and microbes.
- The expert opinion emphasizes that the environmental conditions and the host’s bodily state influence the survival and metabolic changes of these yeasts, which can lead to the development of skin diseases with varying symptoms.
Introduction: is a major component of the skin microbiome, a lipophilic symbiotic organism of the mammalian skin, which can switch to opportunistic pathogens triggering multiple dermatological disorders in humans and animals. This phenomenon is favored by endogenous and exogenous host predisposing factors, which may switch from a commensal to a pathogenic phenotype.
Area Covered: This review summarizes and discusses the most recent literature on the pathogenesis of yeasts, which ultimately results in skin disorders with different clinical presentation.
Article Synopsis
- The study investigates the virulence factors of Malassezia furfur, focusing on its role in bloodstream infections (BSI) and its activity in pityriasis versicolor (PV).
- M. furfur strains from BSI patients exhibited higher biofilm production compared to those from PV patients, but displayed lower enzymatic activities like phospholipase, lipase, and hemolysin.
- Antifungal susceptibility testing revealed that drugs like itraconazole and posaconazole were most effective against M. furfur, with minimum inhibitory concentrations indicating a stronger resistance profile in strains from BSI patients compared to those from PV patients.
yeasts have recently gained medical importance as emerging pathogens associated with a wide range of dermatological and systemic infections. Since standardized methods for in vitro antifungal susceptibility testing have not yet been established for spp., related diseases are always treated empirically.
View Article and Find Full Text PDFUnlabelled: Over the last decade, Malassezia species have emerged as increasingly important pathogens associated with a wide range of dermatological disorders and bloodstream infections. The pathogenesis of Malassezia yeasts is not completely clear, but it seems to be strictly related to Malassezia strains and hosts and needs to be better investigated. This study aimed to assess the enzymatic activities, biofilm formation and in vitro antifungal profiles of Malassezia spp.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the characteristics of pityriasis versicolor (PV) in Tunisia, focusing on the prevalence and identification of Malassezia species in patients.
- A total of 120 PV patients were analyzed, revealing that young adults were most affected, predominantly on the back and neck, with a significant portion experiencing itching and recurrence.
- The most commonly isolated species were M. furfur and M. globosa, with a high concordance between phenotypic and molecular identification methods, highlighting the diagnostic importance of both approaches despite variations in regional species distribution.