root bark extract ameliorates paracetamol-induced liver toxicity in rats possibly via the attenuation of oxidative stress.

root bark is widely used in folk medicine to manage liver diseases, particularly, jaundice but its effect on paracetamol-induced liver toxicity (PILT) has not yet been validated. This study explored the ameliorative effect of ethanolic root bark extract of (ZAE) against PILT in rats. The flavonoid and phenolic content of ZAE was evaluated using Folin-Ciocalteau and aluminium trichloride colorimetric methods, respectively.

Antidepressant and Anxiolytic Effects and Subacute Toxicity of the Aerial Parts of J.B.Hall (Rubiaceae) in Murine Models.

Background: The present study aimed at validating the traditional use and toxicity profile of a methanolic extract of the aerial parts of in alleviating depression and anxiety disorders.

Method: The antidepressant effect of methanolic extract of (PAE 30, 100, and 300 mg/kg, .) was assessed in mice using the forced swim test (FST) and the tail suspension test (TST).

Seed Extract Attenuates the Ethanol-Induced Gastric Ulcer in Rats via the Inhibition of TNF- and INF- Levels and Modulation in the Expression of Ki67 Protein.

has been used to treat an upset stomach in African traditional medicine, but its efficacy and safety have not been scientifically studied. The present research is aimed at assessing the antiulcer property of the seed extract of the plant to validate its traditional claim. Rats were pretreated with three doses of aqueous extract of .