Viperin is anti-viral but is dispensable for restricting dengue virus replication or induction of innate and inflammatory responses .

Viperin has antiviral function against many viruses, including dengue virus (DENV), when studied in cells in culture. Here, the antiviral actions of viperin were defined both and in a mouse model of DENV infection. Murine embryonic fibroblasts (MEFs) derived from mice lacking viperin (vip) showed enhanced DENV infection, accompanied by increased IFN-β and induction of ISGs; IFIT1 and CXCL-10 but not IRF7, when compared to wild-type (WT) MEFs.