Pharmacokinetic Modeling of F-FDOPA PET in the Human Brain for Early Parkinson's Disease.

Objectives: Early detection is essential for the treatment approaches of Parkinson's disease (PD). Clinical criteria alone may be insufficient to distinguish early PD from other conditions. This study aimed to investigate the transfer rate constants of 6-F-fluoro-L-dopa (F-FDOPA) in positron emission tomography (PET) brain images as a sensitive parameter to detect early PD.