Transplantation of autologous cultivated oral mucosal epithelial sheets for limbal stem cell deficiency at Siriraj Hospital: a case series.

Background: The loss of limbal stem cells owing to either corneal burn or inflammation leads to the repopulation of opaque skin over the raw surface of the cornea. It has been proposed that reconstitution of oral mucosal stem cells over this raw surface will mimic the limbal stem cells and restore vision. The efficacy and safety of applying a sheet of cultivated oral mucosal cells as an autologous graft for corneal replacement were evaluated.

Keratoconus in Patients with Macular Stromal Dystrophy.

Objective: To show the association between keratoconus and macular dystrophy.

Material And Method: All patients with macular dystrophy and associated clinical findings leading to a diagnosis of keratoconus by corneal topography were retrospectively reviewed during a 10-year period. Uncorrected and best-corrected visual acuity, automated refraction, manifest refraction, corneal thickness, and corneal curvature by corneal topography were evaluated

Results: Three patients with macular dystrophy exhibiting decreased vision, multifocal white dense deposits, and haze surrounding the deposits in the corneal stroma were evaluated.

Clinical features of Acanthamoeba keratitis in contact lens wearers and non-wearers.

Clinical presentations of patients with Acanthamoeba keratitis (AK) attending the Faculty of Medicine Siriraj Hospital during 1996-2006 were reviewed. The studied parameters included history of ocular trauma, use of contact lenses, associated eye diseases, systemic diseases, visual acuity, symptoms, signs, treatment, visual outcomes, and sequelae. Data were analyzed by comparing non-contact lens (nCL) and contact lens (CL) wearers with eachother.

Risk factors for contact lens related microbial keratitis: a case-control study.

Objective: To evaluate the risk factors that may contribute to microbial keratitis in contact lens wearers.

Material And Method: This prospective case-control study included 52 patients with contact lens related keratitis treated between 1 December 2006 and 15 October 2007 at the Faculty of Medicine, Siriraj Hospital. Controls were sixty-three contact lens users attending with disorders unrelated to contact lens wear All subjects with informed consent were interviewed about demographic data, types of contact lens and contact lens solutions, contact lens use past the recommended replacement date, overnight wear, and lens hygiene.

Refractive outcomes of femtosecond LASIK for myopic correction at Siriraj Hospital, Thailand.

Objective: To evaluate refractive outcomes of myopic femtosecond LASIK at Siriraj Hospital, Thailand.

Material And Method: A retrospective study of patients who underwent femtosecond LASIK at SiLASIK center Siriraj hospital, Mahidol University, Thailand,from April 2009 to April 2010 was conducted. All patients had completely normal preoperative eye examination.

Efficacy of amniotic membrane patching for acute chemical and thermal ocular burns.

Objective: To study the efficacy of amniotic membrane patching (AMP) for acute chemical and thermal ocular burns and compare the results with a control group.

Material And Method: Fifteen patients (21 eyes) with acute ocular burn severity grading of II to IV were retrospectively reviewed. Thirteen eyes were treated with preserved AMP while eight eyes were treated with conventional treatment.

Tonometry after laser in situ keratomileusis treatment: a preliminary study in Thai patients.

Objective: To evaluate the change in intraocular pressure (IOP) measurement by Goldmann applanation tonometer after Laser in Situ Keratomileusis (LASIK) for myopia and myopic astigmatism, and to assess the correlation between the changes of lOP reading and the reduction of central corneal thickness (CCT) after LASIK in Thai patients.

Study Design: Prospective correlational study.

Material And Method: LASIK was performed on 65 eyes of 33 patients for correction of myopia and myopic astigmatism.

Topical 0.002% mitomycin C for the treatment of conjunctival-corneal intraepithelial neoplasia and squamous cell carcinoma.

Purpose: To demonstrate the efficacy of topical 0.002% mitomycin C (MMC) as an adjunctive and alternative treatment in primary and recurrent conjunctival-corneal intraepithelial neoplasia (CCIN) and squamous cell carcinoma (SCC).

Methods: The medical records of 7 patients with histopathologically confirmed CCIN and conjunctival SCC were retrospectively reviewed.

Application of Preserved Human Amniotic Membrane for Corneal Surface Reconstruction.

Objective: To evaluate the efficacy of preserved human amniotic membrane transplantation for reconstruction of the corneal surface diseases.Methods: Preserved human amniotic membrane transplantations were performed in 84 eyes of 78 patients for corneal surface reconstruction. The indications were limbal stem cell deficiency from Steven-Johnson syndrome, chemical burn and herpes keratitis (27 eyes), bullous keratopathy (26 eyes), persistent epithelial defect and dellen (17 eyes), band keratopathy (11 eyes), preparing for prosthesis (1 eye), corneal ulcer (1 eye) and acute chemical burn (1 eye).

Comparison of topical lomefloxacin 0.3 per cent versus topical ciprofloxacin 0.3 per cent for the treatment of presumed bacterial corneal ulcers.

Purpose: To compare the efficacy and safety of topical lomefloxacin 0.3 per cent with topical ciprofloxacin 0.3 per cent for treating mildly severe suspected bacterial corneal ulcers.