Effect of dopamine receptor stimulation on voltage-dependent fast-inactivating Na(+) currents in medial prefrontal cortex (mPFC) pyramidal neurons in adult rats.

Impaired working memory is a common feature of neuropsychiatric disorders. It is dependent on control of the medial prefrontal cortex (mPFC) neurons by dopamine. The purpose of this study was to test the effects of a D1/5-type dopamine receptor agonist (SKF 38393, 10 microM) on the membrane potential and on voltage-dependent fast-inactivating Na+ currents in mPFC pyramidal neurons obtained from adult (9-week-old) rats.