Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia.

Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemia/reperfusion (I/R) injury remains incomplete. We here investigated macrophage lineages and ablated tissue macrophages in homeostasis and after I/R injury in a CSF1R-dependent manner.

Multiphoton In Vivo Microscopy of Embryonic Thrombopoiesis Reveals the Generation of Platelets through Budding.

Platelets are generated by specialized cells called megakaryocytes (MKs). However, MK's origin and platelet release mode have remained incompletely understood. Here, we established direct visualization of embryonic thrombopoiesis in vivo by combining multiphoton intravital microscopy (MP-IVM) with a fluorescence switch reporter mouse model under control of the platelet factor 4 promoter ().

Differences in Cell-Intrinsic Inflammatory Programs of Yolk Sac and Bone Marrow Macrophages.

Background: Tissue-resident macrophages have mixed developmental origins. They derive in variable extent from yolk sac (YS) hematopoiesis during embryonic development. Bone marrow (BM) hematopoietic progenitors give rise to tissue macrophages in postnatal life, and their contribution increases upon organ injury.

BSN graduates' perceptions of liberal education.

An integrative, professional nursing curriculum grounded in liberal education has the capacity to prepare empowered, competent, and humanistic nurses as well as informed, democratic citizens. The purpose of this qualitative research study was to explore the meaning of the lived- experience of recent Bachelor of Science in Nursing (BSN) graduates from a small private college in a curriculum grounded in a liberal education. The phenomenological psychological philosophy of Paul Colaizzi (1978) provided the theoretical foundation for this study.

Support group for families of acute neurological patients.

A family support group is an adjunct to the successful care of the patient and family experiencing an acute neurological disorder. The research base and theoretical framework for a family support group are explored. Organizational issues in the initiation and maintenance of a family support group are described.