Publications by authors named "Winston R Vetharoy"
Article Synopsis
- The ALK(F1174L) mutation contributes to resistance against the cancer drug crizotinib and works together with MYCN in neuroblastoma, a type of cancer common in children.
- Researchers created a mouse model to study the effects of overexpressing both ALK(F1174L) and MYCN, finding that tumors developed earlier and were more aggressive compared to those with just one of these factors.
- The study also revealed that the combination of these two oncogenes activates certain signaling pathways that promote cancer growth, and using an mTOR inhibitor called Torin2 could potentially counteract the drug resistance seen in these tumors.
