Simulated bupivacaine pharmacokinetics after labor epidural analgesia followed by transversus abdominis plane block with liposomal bupivacaine for intrapartum cesarean delivery.

Study Objective: To simulate bupivacaine pharmacokinetics in scenarios of labor epidural analgesia (LEA) extended for intrapartum cesarean delivery (CD) with epidural or intrathecal boluses, followed by transversus abdominis plane (TAP) block with liposomal bupivacaine (LB) for postcesarean analgesia.

Design: Bupivacaine plasma concentrations were simulated using a 2-compartment distribution model fit to previous study data.

Setting: Virtual pharmacokinetic simulations.

Mosquito abundance and diversity in central Ohio, USA vary among stormwater wetlands, retention ponds, and detention ponds and their associated environmental parameters.

Mosquitoes (Diptera: Culicidae) are one of the most impactful pests to human society, both as a nuisance and a potential vector of human and animal pathogens. Mosquito larvae develop in still aquatic environments. Eliminating these habitats near high human density or managing them to reduce the suitability for mosquitoes will reduce mosquito populations in these human environments and decrease the overall negative impact of mosquitoes on humans.

Holistic evaluation of inlet protection devices for sediment control on construction sites.

To address the deleterious impacts of excess soil erosion from the construction sites, the United States Clean Water Act requires that erosion and sediment control measures (ESCs) be implemented on construction projects disturbing more than 0.4 ha. Inlet protection devices (IPDs) are a common ESC utilized on construction projects to reduce the amount of sediment entering storm sewers.

Longitudinal Analysis of Urban Stormwater Microbiome and Resistome from Watersheds with and without Green Infrastructure using Long-Read Sequencing.

Since stormwater conveys a variety of contaminants into water bodies, green infrastructure (GI) is increasingly being adopted as an on-site treatment solution in addition to controlling peak flows. The purpose of this study was to identify differences in microbial water quality of stormwater in watersheds retrofitted with GI vs. those without GI.

Extended-Release Versus Immediate-Release Triamcinolone Acetonide in Patients Who Have Knee Osteoarthritis and Type 2 Diabetes Mellitus.

Background: Intra-articular corticosteroid injections may cause hyperglycemia (glucose level >180 mg/dL). In a phase 2 study of 33 patients who had osteoarthritis of the knee and type 2 diabetes mellitus, triamcinolone acetonide extended-release (TA-ER) was associated with minimal glycemic control disruption compared with triamcinolone acetonide immediate-release (TA-IR). This post hoc analysis characterizes the clinical relevance of these results.

Urban stormwater green infrastructure: Evaluating the public health service role of bioretention using microbial source tracking and bacterial community analyses.

Bioretention cells (BRCs) control stormwater flow on-site during precipitation, reducing runoff and improving water quality through chemical, physical, and biological processes. While BRCs are effective in these aspects, they provide habitats for wildlife and may face microbial hazards from fecal shedding, posing a potential threat to human health and the nearby environment. However, limited knowledge exists regarding the ability to control microbial hazards (e.

Monitoring the impacts of rainfall characteristics on sediment loss from road construction sites.

Exposed soils associated with active construction sites provide opportunities for erosion and sediment transport during storm events, introducing risks associated with excess sediment to downstream infrastructure and aquatic biota. A better understanding of the drivers of sediment transport in construction site runoff is needed to improve the design and performance of erosion and sediment control measures (ESCMs). Eleven monitoring locations on 3 active road construction sites in central Ohio were established to characterize runoff quality from points of concentrated flow during storm events.

The potential to manage releases of Bacillus anthracis using bioretention and a high flow media filter: Results of simulated runoff testing with tracer spores Bacillus globigii.

The threat of bioterrorism has spurred research on the decontamination and containment of different agents. Anthrax [causative agent Bacillus anthracis (Ba)] is a disease that can lead to severe infections within human and animals, particularly when inhaled. This research investigated the use of spore-contaminated simulated runoff events into stormwater control measures (SCMs), which are designed to retain and improve the quality of runoff and may have the potential to filter and contain the spores.

A phase 3 active-controlled trial of liposomal bupivacaine via sciatic nerve block in the popliteal fossa after bunionectomy.

Study Objective: To investigate the efficacy, safety, pharmacodynamics, and pharmacokinetics of liposomal bupivacaine (LB) administered via ultrasound-guided sciatic nerve block in the popliteal fossa in participants undergoing bunionectomy.

Design: Two-part, randomized, double-blind, active-controlled trial (NCT05157841).

Setting: Operating room, postanesthesia care unit, and health care facility (6 sites).

Measuring sediment loads and particle size distribution in road runoff: Implications for sediment removal by stormwater control measures.

Road runoff contributes an array of pollutants which degrade the quality of receiving waters. Sediment conveyed in runoff results in loss of habitat and loss of reservoir capacity, among other undesirable impacts. To select and design stormwater control measures (SCMs), the sediment particle size distribution (PSD) is needed to quantify the required hydraulic retention time for particle settling and to understand what other treatment processes (e.

Environmental regulations in the United States lead to improvements in untreated stormwater quality over four decades.

Identifying sources of pollutants in watersheds is critical to accurately predicting stormwater quality. Many existing software used to model stormwater quality rely on decades-old data sets which may not represent current runoff quality in the United States. Because of environmental regulations promulgated at the federal level over previous decades, there is a need to understand long-term trends (and potential shifts) in runoff quality to better parameterize models.

Curbing sediment: The effects of added surface roughness in the curb and gutter as a novel pretreatment for green infrastructure stormwater control measures.

Stormwater control measures (SCMs) are employed to reduce the multitude of deleterious impacts of urban runoff on receiving waters. Sediment accumulation in infiltration-based SCMs can clog these systems, resulting in lack of hydraulic function and reduced stormwater treatment efficacy. As such, pretreatment devices, such as forebays, filter strips, or catch basin sumps, are typically employed upstream of SCMs to remove sediment and prolong maintenance intervals.

Abundance and composition of anthropogenic macrolitter and natural debris in road runoff in Ohio, USA.

Urban stormwater conveys dissolved pollutants, micropollutants, particulate matter, natural debris, and anthropogenic macrodebris to receiving waters. Though it is widely recognized that anthropogenic macrodebris mobilized by stormwater contributes to global pollution management issues (e.g.

Experiential Learning for Prelicensure Nursing Students: A Pediatric Special Needs Respite Program.

Background: A respite program at a southeastern university was developed to provide respite services to local families of children with special needs and to integrate a hands-on clinical experience for nursing students.

Method: To assess the nursing students' perceptions of participating in the respite program experience, a survey was administered to prelicensure nursing students.

Results: Analysis of survey data revealed all participants were satisfied with the respite experience, perceived they will be able to apply knowledge obtained, and acknowledged opportunities to enhance soft skills.

Abundance, distribution, and composition of microplastics in the filter media of nine aged stormwater bioretention systems.

Bioretention systems are designed for quality treatment of stormwater. Particulate contaminants are commonly treated efficiently and accumulate mainly in the surface layer of the bioretention filter material. However, concerns exist that microplastic particles may not show equal accumulation behavior as other sediment particles.

Monitoring the effects of urban and forested land uses on runoff quality: Implications for improved stormwater management.

Urban stormwater is a substantial source of non-point source pollution. Despite considerable monitoring efforts, little is known about stormwater quality in certain geographic regions. These spatial gaps induce uncertainty when extrapolating data and reduce model calibration capabilities, thereby limiting pollutant load reduction strategies.

Occurrence, concentration, and distribution of 38 organic micropollutants in the filter material of 12 stormwater bioretention facilities.

The increased use of bioretention facilities as a low impact development measure for treating stormwater runoff underscores the need to further understand their long-term function. Eventually, bioretention filter media must be (partly) replaced and disposed of at the end of its functional lifespan. While there are several studies of metal accumulation and distributions in bioretention media, less is known about organic pollutant pathways and accumulation in these filters.

Wastewater surveillance of SARS-CoV-2 in dormitories as a part of comprehensive university campus COVID-19 monitoring.

Wastewater-based epidemiology is an effective tool for monitoring infectious disease spread or illicit drug use within communities. At the Ohio State University, we conducted a SARS-CoV-2 wastewater surveillance program in the 2020-2021 academic year and compared results with the university-required weekly COVID-19 saliva testing to monitor COVID-19 infection prevalence in the on-campus residential communities. The objectives of the study were to rapidly track trends in the wastewater SARS-CoV-2 gene concentrations, analyze the relationship between case numbers and wastewater signals when adjusted using human fecal viral indicator concentrations (PMMoV, crAssphage) in wastewater, and investigate the relationship of the SARS-CoV-2 gene concentrations with wastewater parameters.

LGBQ-affirmative cognitive-behavioral therapy for young gay and bisexual men's mental and sexual health: A three-arm randomized controlled trial.

Objective: Effective Skills to Empower Effective Men (ESTEEM) represents the first intervention to address the psychological pathways through which minority stress undermines young sexual minority men's (SMM's) mental and sexual health using transdiagnostic cognitive-behavioral therapy. This study compared the efficacy of ESTEEM against two existing interventions.

Method: Participants were young HIV-negative SMM ( = 254; ages = 18-35; 67.

Optimizing floating treatment wetland and retention pond design through random forest: A meta-analysis of influential variables.

Floating treatment wetlands (FTWs), artificial systems constructed from buoyant mats and planted with emergent macrophytes, represent a potential retrofit to enhance the dissolved nutrient removal performance of existing retention ponds. Treatment occurs as water flows through the dense network of roots suspended in the water column, providing opportunities for pollutants to be removed via filtration, sedimentation, plant uptake, and adsorption to biofilms in the root zone. Despite several recent review articles summarizing the growing body of research on FTWs, FTW design guidance and strategies to optimize their contributions to pollutant removal from stormwater are lacking, due in part to a lack of statistical analysis on FTW performance at the field scale.

Background splicing as a predictor of aberrant splicing in genetic disease.

Mutations of splice sites, auxiliary splicing elements and the splicing machinery cause a wide range of genetic disease. Here we report that many of the complex effects of splicing mutations can be predicted from background splicing information, with emphasis on BRCA1, BRCA2 and DMD. Background splicing arises from very low level splicing between rarely used background splice sites and from low-level exon skipping between intron splice sites.