Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone.

Operationally simple, stereocontrolled semisyntheses of the anticancer rotenoids elliptone and 12aβ-hydroxyelliptone, isolated from Derris elliptica and Derris trifoliata, respectively, are described. Inspired by the work of Singhal, elliptone was prepared from rotenone via a dihydroxylation-oxidative cleavage, chemoselective Baeyer-Villiger oxidation, and acid-catalyzed elimination sequence. Elaboration of elliptone to 12aβ-hydroxyelliptone was achieved via a diastereoselective chromium-mediated Étard-like hydroxylation.

The relationship between degree of facet tropism and amount of dynamic disc bulge in lumbar spine of patients symptomatic for low back pain.

Facet tropism has been investigated as a predisposing factor for degenerative changes in the lumbar spine; however, no prior study has evaluated the relationship between disc bulge and facet tropism. In this study, we used kinetic magnetic resonance imaging (kMRI) to investigate the association between degree of facet tropism and amount of disc bulge in the lumbar spine in relation to age. kMRIs in the flexion, neutral, and extension positions were performed on 410 consecutive patients with low back pain.

Can bone morphogenetic protein binding peptide increase efficiency of bone formation?

Study Design: The role of bone morphogenetic protein binding peptide (BBP) in bone formation is reviewed from basic science studies and potential clinical application.

Objective: We review the discovery and early scientific studies of BBP with emphasis on potential future clinical applications.

Summary Of Background Data: Biologics delivered locally to enhance bone formation are of increasing importance, particularly in spinal fusion.

The treatment of unstable ankle fractures in patients over eighty years of age.

Background: The current study examined the outcomes of operative treatment of unstable ankle fractures in patients at least 80 years old at the time of injury.

Methods: Of 2,682 patients who presented for treatment of ankle fractures, 17 patients met the study criteria. These patients had open reduction and internal fixation after sustaining 15 closed and two open unstable ankle fractures.