Influence of bisphosphonate treatment on bone substitute performance in osteoporotic conditions.

Objective: Considering the elevated number of osteoporotic patients in need of bone graft procedures, we here evaluated the effect of alendronate (ALN) treatment on the regeneration of bone defects in osteoporotic rats. Bone formation was histologically and histomorphometrically assessed in rat femoral condyle bone defects filled with bone graft (Bio-Oss®) or left empty.

Methods: Male Wistar rats were induced osteoporotic through orchidectomy (ORX) and SHAM-operated.