An immunoassay system to investigate epidemiology of (rat hepatitis E virus) infection in humans.

Background & Aims: Rat hepatitis E virus (; HEV-C1) is an emerging cause of hepatitis E that is divergent from conventional human-infecting HEV variants (; HEV-A). Validated serological assays for HEV-C1 are lacking. We aimed to develop a parallel enzymatic immunoassay (EIA) system that identifies individuals with HEV-C1 exposure.