A case of Cushing's syndrome in pregnancy.

Cushing's syndrome (also known as hypercortisolemia) is rare in pregnant women due to the menstrual disturbances and infertility in women with hypercortisolism. A diagnosis of pathological hypercortisolism in pregnant women is often difficult as some symptoms of the disease may be associated with a complicated pregnancy. Hypercortisolemia leads to serious complications for mother and foetus, and is associated with premature labour and high foetal mortality.

Immunohistochemical evaluation of metallothionein, Mcm-2 and Ki-67 antigen expression in tumors of the adrenal cortex.

Background: The aim of this study was to assess the metallothionein (MT), maintenance protein 2 (Mcm-2) and Ki-67 expressions in adrenocortical adenomas and carcinomas in comparison to normal tissue and evaluate the correlations between these markers of proliferation and between these markers and tumor diameter.

Materials And Methods: The expression of MT, Mcm-2 and Ki-67 was assessed by immunochemistry in forty-eight adrenocortical adenomas, six adrenocortical carcinomas and eleven normal adrenal cortex tissue samples.

Results: The expressions of MT, Mcm-2 and Ki-67 in the adrenocortical carcinomas were significantly higher than in the adenomas and normal tissue (p<0.

Breast cancer and long-term hormonal treatment of male hypogonadism.

Breast cancer in men is rare and its etiology is multifactorial. Androgens may promote the development of breast carcinoma in men though data on the subject is scarce. We observed 45 men with hypergonadotropic hypogonadism (aged 18-57) who received 250 mg of testosterone esters (Omnadren 250, Jelfa, Poland) every 3-4 weeks for 5-26 years.

[Bone turnover markers in patients with leg ischemia before and after revascularization].

In patients with leg ischemia bone metabolism impairment has been observed. The aim of this study was to investigate the biochemical bone metabolism markers. Elevated level of osteolysis markers was observed before and 7 days after revascularization the level of markers was unchanged.

[Comparison of combined treatment for venous ulcers in postphlebitic syndrome and use of PGE-1--introductory remarks].

We have included PGE-1 to the clinical management of varicose ulcers of the leg. We found the results very interesting and promising. The literature on using PGE-1 for this disease entity is rather poor and the biomechanics is still unclear.

[Results of tests with clomiphene and choriogonadotropin in men with oligozoospermia treated with longterm antiestrogens].

The evaluation was made of the response to testosterone and oestradiol in the test (50 mg twice daily for 10 days) and HCG test (6000 units of Biogonadyl through 2 days) performed on 21 normospermic (fertile) males and on patients with normogonadotropic, idiopathic oligozoospermia, positively (12 patients) or negatively (24 males) reacting to the longterm Clostilbegyt treatment (50 mg daily for 240 days). It was shown that patients with oligozoospermia who do not react with an increase of spermatozoa during the longterm antioestrogen treatment had higher response of oestradiol in the dynamic test (+ 118.9%) than the normospermic males (+ 60.

[Coexistence of retrosternal goiter and mediastinal lipoma simulating mediastinal goiter].

A female patient is reported in whom the preliminary diagnosis was mediastinal goitre. During the operation retrosternal goitre was found to be associated with mediastinal tumour diagnosed histologically as lipoma.