Publications by authors named "Winnie Zhao"

The parental environment of can have lasting effects on progeny development and immunity. Vitamin B12 exposure in has been shown to accelerate development and protect against pathogenic bacteria. Here, we show that parental exposure to dietary vitamin B12 or vitamin B12-producing bacteria results in offspring with accelerated growth that persists for a single generation.

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Animals are under constant selective pressure from a myriad of diverse pathogens. Microsporidia are ubiquitous animal parasites, but the influence they exert on shaping animal genomes is mostly unknown. Using multiplexed competition assays, we measured the impact of four different species of microsporidia on 22 wild isolates of Caenorhabditis elegans.

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Article Synopsis
  • This study investigates Argonaute (AGO) proteins in nematodes, an organism with 19 functional AGOs, which play a key role in interacting with small RNAs to regulate gene expression.
  • Researchers used CRISPR-Cas9 to tag each AGO for tracking its expression through development and to examine its small RNA interactions and the effects of losing specific AGOs.
  • The findings reveal that AGOs group into distinct regulatory modules and highlight new stress-induced fertility and pathogen response issues linked to AGO loss.
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Microsporidia are a diverse group of fungal-related obligate intracellular parasites that infect most animal phyla. Despite the emerging threat that microsporidia represent to humans and agricultural animals, few reliable treatment options exist. Here, we develop a high-throughput screening method for the identification of chemical inhibitors of microsporidia infection, using liquid cultures of Caenorhabditis elegans infected with the microsporidia species Nematocida parisii.

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Invasive species are the second main cause of biodiversity loss because of their exceptional ability to supplant native species by creating major upheavals in ecosystems. Inexpensive and prevalent time-lapse photography provides an exciting opportunity to better understand the aggressive behavior of invasive species including how they invade and conquer new territory. One of the most pervasive invasive species in the Eastern United States is Japanese stiltgrass, (Trin.

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Parental infection can result in the production of offspring with enhanced immunity phenotypes. Critically, the mechanisms underlying inherited immunity are poorly understood. Here, we show that infected with the intracellular microsporidian parasite produce progeny that are resistant to microsporidia infection.

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Background: Research suggests that sport facilitates belonging for diverse athletes. This scoping review characterizes literature on sport participation and belonging for young adults with intellectual and developmental disabilities.

Materials And Methods: A search of five databases identified 17,497 articles.

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