Publications by authors named "Winnie W Y Yeung"
Article Synopsis
- A study found that for rheumatoid arthritis patients who didn't respond to methotrexate, starting treatment with biosimilar DMARDs (like biosimilar infliximab) resulted in better clinical outcomes than conventional DMARDs, but cost-effectiveness data is still uncertain.
- The aim was to assess the cost-effectiveness of starting biosimilar DMARD treatment after methotrexate failure compared to leflunomide, utilizing a Markov model to simulate long-term disease progression and costs based on local patient data from Hong Kong.
- The analysis revealed that treating with leflunomide resulted in higher lifetime healthcare costs and fewer quality-adjusted life-years (QALYs) than bios
Objectives: Lupus nephritis (LN) remains one of the most severe manifestations in patients with systemic lupus erythematosus (SLE). Onset and overall LN risk among SLE patients remains considerably difficult to predict. Utilizing a territory-wide longitudinal cohort of over 10 years serial follow-up data, we developed and validated a risk stratification strategy to predict LN risk among Chinese SLE patients - Risk and Factors associated with disease manifestations in systemic Lupus Erythematosus - Lupus Nephritis (RIFLE-LN).
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- The study investigated the impact of the first infliximab biosimilar on overall infliximab consumption and pricing in eight regions from 2010 to 2020.
- Results indicated that following the biosimilar's introduction, infliximab consumption increased in Australia, Canada, the UK, and Hong Kong, while the list price of the original infliximab decreased in these same regions.
- However, the effects on consumption and pricing were inconsistent in India, Japan, Korea, and the USA, suggesting that more support is needed for biosimilar adoption across different healthcare systems.
Recent literature indicates that patients with depression had increased immune activation. We hypothesised that treatment-resistant depression (TRD), an indicator of non-responsive depression with long-term dysregulated inflammation, could be an independent risk factor for subsequent autoimmune diseases. We performed a cohort study and a nested case-control study to examine the association between TRD and risk of autoimmune diseases, and to explore potential sex-specific difference.
View Article and Find Full Text PDFDelayed hypersensitivity reaction of penicillin is commonly seen, but never reported in pyridium. This case illustrates a patient with delayed hypersensitivity reaction after the use of augmentin and pyridium. Skin patch test, surprisingly, confirmed pyridium delayed hypersensitivity.
View Article and Find Full Text PDFObjectives: To investigate the relationship between COVID-19 full vaccination (two completed doses) and possible arthritis flare.
Methods: Patients with rheumatoid arthritis (RA) were identified from population-based electronic medical records with vaccination linkage and categorised into BNT162b2 (mRNA vaccine), CoronaVac (inactive virus vaccine) and non-vaccinated groups. The risk of possible arthritis flare after vaccination was compared using a propensity-weighted cohort study design.
Behcet's Disease Diagnosed by Allergy Skin Testing and Positive Pathergy Test.
J Allergy Clin Immunol Pract
April 2021
Background: Drug allergies (DA) are immunologically mediated adverse drug reactions and their manifestations depend on a variety of drug- and patient-specific factors. The dysregulated immune system underpinning rheumatological diseases may also lead to an increase in hypersensitivity reactions, including DA. The higher prevalence of reported DA, especially anti-microbials, also restricts the medication repertoire for these already immunocompromised patients.
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