Signed-gradient adaptive step size LMS algorithm for biomedical applications.

Gradient adaptive step size adaptive filters have been widely used to adapt different biomedical application environments and obtain useful life signals from serious ambient noise and interferences. In order to further improve the signal-to-noise ratio (SNR) of the life signals, this paper presents a class of signed-gradient adaptive step size least mean square (LMS) adaptive filters. The proposed algorithms introduce a sign function to replace the gradient of squared error in the step size updating process of the gradient adaptive step size LMS adaptive filters.

Influence of bio-coatings on the recording performance of neural electrodes.

Neural probes are complex devices consisting of metallic (often Pt based) electrodes, spread over an insolating/dielectric backbone. Their functionality is often limited in time because of the formation of scaring tissues around the implantation tracks. Functionalization of the probes surface can be used to limit the glial scar reaction.

A novel gradient adaptive step size LMS algorithm with dual adaptive filters.

Least mean square (LMS) adaptive filter has been used to extract life signals from serious ambient noises and interferences in biomedical applications. However, a LMS adaptive filter with a fixed step size always suffers from slow convergence rate or large signal distortion due to the diversity of the application environments. An ideal adaptive filtering system should be able to adapt different environments and obtain the useful signals with low distortion.

Performance of a biomimetic oxidation catalyst immobilized on silicon wafers: comparison with its gold congener.

With the aim of extending the usefulness of an existing biomimetic catalytic system, cobalt porphyrin catalytic units with thiol linkers were heterogenized via chemical grafting to silicon wafers and utilized for the catalytic oxidation of hydroquinone to p-benzoquinone. Atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS) were used to analyze the morphology and composition of the heterogeneous catalyst. The results of the catalytic oxidation of hydroquinone obtained with porphyrins grafted on silicon were compared with those obtained earlier with the same catalyst in homogeneous phase and immobilized on gold.

Two-dimensional biosensor arrays based on surface plasmon resonance phase imaging.

We present a biosensor design based on capturing the two-dimensional (2D) phase image of surface plasmon resonance (SPR). This 2D SPR imaging technique may enable parallel label-free detection of multiple analytes and is compatible with the microarray chip platform. This system uses our previously reported differential phase measurement approach, in which 2D phase maps obtained from the signal (P) and reference (S) polarizations are compared pixel by pixel.