Constituents of with Potential Anti-HIV Activity.

Reported herein is an anti-HIV monochlorinated compound, 1β-acetoxy-3β-chloro-5α,6α-dihydroxycrotocascarin L (), of the rare crotofolane diterpenoid class. Compound , a suspected artifact of extraction, along with the previously undescribed 11β-acetoxycrotocascarin L () and a known compound, crotocascarin K (), were isolated from the bark of , a Kenyan oil-producing seed crop. Compounds and inhibited HIV-1 replication with IC values of 28 and 5.

HIV-1 Integrase Inhibitory Effects of Major Compounds Present in CareVid™: An Anti-HIV Multi-Herbal Remedy.

In our continued study on the anti-HIV activity of compounds present in CareVid, we report the HIV-1 integrase ((HIV-1 IN) inhibitory effects of pellitorine (), oleuropein (), magnoflorine (), crotepoxide (), -kaurane-16β,17-diol (), crotocorylifuran (), lupeol (), betulin (), and ellagic acid () in an in vitro enzyme assay, and in an in silico study. Ellagic acid, pellitorine, lupeol, and betulin showed an in vitro percentage inhibition against HIV-1 IN of 21.1%, 19.

HIV-1 Reverse Transcriptase Inhibition by Major Compounds in a Kenyan Multi-Herbal Composition (CareVid™): In Vitro and In Silico Contrast.

CareVid is a multi-herbal product used in southwest Kenya as an immune booster and health tonic and has been anecdotally described as improving the condition of HIV-positive patients. The product is made up of roots, barks and whole plant of 14 African medicinal plants: (L.) Willd.