A prospective randomised comparison of sublingual and vaginal misoprostol in second trimester termination of pregnancy.

Objective: To compare the efficacy, side effects and acceptability of sublingual and vaginal misoprostol for second trimester medical abortion.

Design: Prospective randomised controlled trial.

Setting: Tertiary referral unit and a teaching hospital.

A prospective randomized study to compare the use of repeated doses of vaginal with sublingual misoprostol in the management of first trimester silent miscarriages.

Background: A randomized controlled trial comparing sublingual with vaginal administration of misoprostol for medical management of silent miscarriages.

Methods: Eighty women who had silent miscarriages (<13 weeks) were randomized to receive 600 micro g of misoprostol every 3 h for a maximum of three doses either sublingually or vaginally.

Results: The success rates of medical management were the same in both groups (87.