No way back? A survey on changes in travel demand post-pandemic in Norway.

Research shows a significant reduction in travel demand during the pandemic. Vaccines are currently distributed, allowing us to go back to pre-COVID-19 life, if that is the case. This study provides insight into changes in activities and travel demand during the pandemic and expected changes after the pandemic.

Designing a Pharmacist Opioid Safety and Intervention Tool.

Background: Despite the recent increase in opioid overdoses across Canada, few pharmacy-led initiatives have been implemented to address issues related to opioid prescribing in the hospital setting.

Objectives: The primary objective of this study was to develop a clinical tool, intended for use by hospital pharmacists and informed by best practices from the literature, that would provide a structured approach to enhancing the safety of opioid prescribing. The secondary objective was to collect pharmacists' opinions about the feasibility and utility of this tool.

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18.

Signaling through the adaptor protein myeloid differentiation factor 88 (MyD88) promotes carcinogenesis in several cancer models. In contrast, MyD88 signaling has a protective role in the development of azoxymethane (AOM)/dextran sodium sulfate (DSS) colitis-associated cancer (CAC). The inability of Myd88(-/-) mice to heal ulcers generated upon injury creates an altered inflammatory environment that induces early alterations in expression of genes encoding proinflammatory factors, as well as pathways regulating cell proliferation, apoptosis, and DNA repair, resulting in a dramatic increase in adenoma formation and progression to infiltrating adenocarcinomas with frequent clonal mutations in the beta-catenin gene.