Low-density lipoprotein receptor mRNA in human breast cancer cells: influence by PKC modulators.

It was reported previously that low-density lipoproteins (LDL) differentially stimulate cell growth of hormone-responsive (ER+) and hormone-unresponsive (ER-) mammary tumor cell lines. Here we examined the mRNA levels of the LDL-receptor (LDL-R) gene with RNAse protection analysis in ER- (MDA-MB-231 and HBL-100) and ER+ (MCF-7 and ZR75-1) cells, and compared them with the estrogen receptor (ER) status. Measurable amounts of ER mRNA were only found in ER+ cells as expected.

PCBs and PCDD/Fs in lake sediments of Grosser Arbersee, Bavarian Forest, South Germany.

Despite their environmental importance, there are still relatively few historical studies of the environmental occurrence of polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), especially in middle Europe. Trends in PCBs and PCDD/Fs were, therefore, assessed in lake sediments of the Grosser Arbersee over the past 130 years (1860-1990). Ballschmiter-PCB concentrations (congeners # 28, 52, 101, 138, 153, 180) increased between 1946 and 1972 from 4.

[Development of surgery for breast carcinoma by Joseph Rotter].

Hundred years ago Joseph Rotter published his new method of operation for breast cancer, by which the rate of local recurrences significant was decreased. This radical mastectomy performed similarly by Halsted in Baltimore (USA) was the surgical standard of the breast cancer therapy for a long time and is still used in local advanced carcinoma until today.

Therapeutic management of grade IV aneurysm patients.

Background: The timing of surgery in patients suffering from subarachnoid hemorrhage grade IV and V according to Hunt and Hess, is still controversial. Several authors advocate early surgery for patients in poor clinical condition. Improved outcome and decreased mortality rates were reported.

Comparison of direct alpha spectrometry and neutron activation analysis of aerosol filters for determination of workplace thorium air concentrations.

Direct alpha spectrometry with three different filter types was investigated for the determination of thorium air concentrations at workplaces in the manufacturing process of discharge lamps containing thoriated tungsten electrodes. The method was compared with neutron activation analysis over an activity range of five orders of magnitude. Within the experimental limits of error, both methods were found to be comparable with respect to sensitivity and accuracy.

The ratio of long-lived to short-lived radon-222 progeny concentrations in ground-level air.

The ratio of 210Pb air concentration to the short-lived radon (222Rn) decay products concentration at ground level was investigated at a semi-rural location 10 km north of Munich, south Germany, for a period of 11 years (1982-1992). The average ratio from 132 monthly mean values has been found to be (7.5 +/- 2.

[Acute abdomen in abdominal actinomycosis].

The case of a female patient aged 34 suffering from abdominal actinomycosis is reported. She underwent emergency surgery for an abscess-forming tumour infiltrating the lateral abdominal wall and giving rise to the clinical picture of acute abdomen. The casuistry is complemented by two further case histories of actinomyces infections in patients with fistulas of the anal region and pilonidal sinus respectively.

[Intramedullary spinal metastasis of bronchial carcinoma coincident with intramedullary spinal angioma].

We report on a case of a man of 51 years, who presented with pain and symptoms of progressive spinal cord compression caused by an intramedullary spinal tumor at T8. Before surgery a bronchial carcinoma was diagnosed. A MRI-study detected an edema of the spinal cord at T8.

The maize Dwarf3 gene encodes a cytochrome P450-mediated early step in Gibberellin biosynthesis.

Gibberellins (GAs) are phytohormones required for normal growth and development in higher plants. The Dwarf3 (D3) gene of maize encodes an early step in the GA biosynthesis pathway. We transposon-tagged the D3 gene using Robertson's Mutator (Mu) and showed that the mutant allele d3.

Combined genetic and physiological analysis of a locus contributing to quantitative variation.

The natural variation of many traits is controlled by multiple genes, individually referred to as quantitative trait loci (QTL), that interact with the environment to determine the ultimate phenotype of any individual. A QTL has yet to be described molecularly, in part because strategies to systematically identify them are underdeveloped and because the subtle nature of QTLs prevents the application of standard methods of gene identification. Therefore, it will be necessary to develop a systematic approach(es) for the identification of QTLs based upon the numerous positional data now being accumulated through molecular marker analyses.

Iodine distribution in a porcine eye model following iontophoresis.

Iodine distribution was studied in isolated porcine eyes after iontophoresis using 131I-labelled solutions and chemical methods. After a 15-min treatment with a therapeutically used iodine brine, the iodine content in the ocular tissues showed the following rank order: cornea > retina > vitreous body > anterior chamber fluid > lens. Replacement of the brine by 0.

Analysis of the autonomy of maize dwarf 1 action in genetic mosaics.

Genetic mosaic maize plants that contained dwarf1 sectors in otherwise normal plants were analyzed. The analysis of dwarf1 sector growth relative to the surrounding wild-type tissue should test the hypothesis that Dwarf1 controls the production of a diffusible factor. Maize dwarf1 sectors did not show altered growth relative to the surrounding tissue, indicating that Dwarf1 controls the production of a diffusible factor.

[Changes in selenium status, antioxidant enzyme activity and lipid peroxide level after drinking cures in Bad Hall health resort].

61 spa patients, predominantly with heart and vascular diseases, were divided into 2 therapeutic groups. In addition to the usual balneotherapeutic program, one group (J) received a course of "iodine brine concentrate" for drinking (2 x 100 ml, daily iodine uptake approximately 9 mg), and the control group (CI) received isotonic NaCl in the same way. The patients were mostly on a reduced-fat and -calorie diet.

[Changes of Glutathione Peroxidase Activity in Eye Tissues of Emory Mice in Relation to Cataract Status and Age].

The relationship between the activity of the antioxidant defense enzyme glutathione peroxidase (GSH-PX) and the degree of cataract (lens opacity) was examined in 14 Emory mice at the age of 2, 7 and 10 months. Significant decreases in specific GSH-PX activity (mU/mg wet tissue) in the lens as well as in the residual eye tissue were found between 2 and 10 months of age, showing a highly significant correlation of this decrease (r = 0.590, p approximately 0.