Accuracy of Dose Calibrators for Ga PET Imaging: Unexpected Findings in a Multicenter Clinical Pretrial Assessment.

We report the discovery of a systematic miscalibration during the work-up process for site validation of a multicenter clinical PET imaging trial using Ga, which manifested as a consistent and reproducible underestimation in the quantitative accuracy (assessed by SUV) of a range of PET systems from different manufacturers at several different facilities around Australia. Sites were asked to follow a strict preparation protocol to create a radioactive phantom with Ga to be imaged using a standard clinical protocol before commencing imaging in the trial. All sites had routinely used Ga for clinical PET imaging for many years.

Results of the CCRI(II)-S12.H-3 supplementary comparison: Comparison of methods for the calculation of the activity and standard uncertainty of a tritiated-water source measured using the LSC-TDCR method.

A comparison of calculations of the activity of a HO liquid scintillation source using the same experimental data set collected at the LNE-LNHB with a triple-to-double coincidence ratio (TDCR) counter was completed. A total of 17 laboratories calculated the activity and standard uncertainty of the LS source using the files with experimental data provided by the LNE-LNHB. The results as well as relevant information on the computation techniques are presented and analysed in this paper.

Preparation and use of standards for a comparison exercise among users of (131)I capsules in South Africa.

(131)I is widely used as a diagnostic radiopharmaceutical and for radiotherapy in the treatment of thyroid cancer and hyperthyroidism. Radionuclide/Dose calibrators are used to measure activities for administering to patients. To check the accuracy of calibrators operated by South African nuclear medicine facilities, comparison exercises were conducted among users of (131)I capsules.