Accuracy of Dose Calibrators for Ga PET Imaging: Unexpected Findings in a Multicenter Clinical Pretrial Assessment.

We report the discovery of a systematic miscalibration during the work-up process for site validation of a multicenter clinical PET imaging trial using Ga, which manifested as a consistent and reproducible underestimation in the quantitative accuracy (assessed by SUV) of a range of PET systems from different manufacturers at several different facilities around Australia. Sites were asked to follow a strict preparation protocol to create a radioactive phantom with Ga to be imaged using a standard clinical protocol before commencing imaging in the trial. All sites had routinely used Ga for clinical PET imaging for many years.

Preparation and use of standards for a comparison exercise among users of (131)I capsules in South Africa.

(131)I is widely used as a diagnostic radiopharmaceutical and for radiotherapy in the treatment of thyroid cancer and hyperthyroidism. Radionuclide/Dose calibrators are used to measure activities for administering to patients. To check the accuracy of calibrators operated by South African nuclear medicine facilities, comparison exercises were conducted among users of (131)I capsules.