Publications by authors named "Winifred C Akwani"
In low-resource settings with high tuberculosis (TB) burdens, lack of rapid diagnostic methods for detection and differentiation of complex (MTBC) is a major challenge affecting TB management. This study utilized comparative genomic analyses of MTBC lineages; , Lineages 5/6 and to identify lineage-specific genes. Primers were designed for the development of a Multiplex PCR assay which was successful in differentiating the MTBC lineages.
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- MABC is a significant pathogen for immunocompromised patients, and identifying its subspecies accurately is crucial for effective antibiotic treatment.
- Researchers developed specific PCR assays for MABC subspecies using comparative genomics, which highlighted distinct genetic clusters among the subspecies.
- The study confirmed that these PCR assays are highly sensitive and specific, allowing for reliable identification of MABC subspecies, thus aiding in better diagnosis and treatment decisions.