Metasurface for programmable quantum algorithms with classical and quantum light.

Metasurfaces have recently opened up applications in the quantum regime, including quantum tomography and the generation of quantum entangled states. With their capability to store a vast amount of information by utilizing the various geometric degrees of freedom of nanostructures, metasurfaces are expected to be useful for processing quantum information. Here, we propose and experimentally demonstrate a programmable metasurface capable of performing quantum algorithms using both classical and quantum light with single photons.

Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair.

Peripheral nerves regenerate successfully; however, clinical outcome after injury is poor. We demonstrated that low-dose ionizing radiation (LDIR) promoted axon regeneration and function recovery after peripheral nerve injury (PNI). Genome-wide CpG methylation profiling identified LDIR-induced hypermethylation of the Fmn2 promoter, exhibiting injury-induced Fmn2 downregulation in dorsal root ganglia (DRGs).

The oncogenic potential of Rab-like protein 1A (RBEL1A) GTPase: The first review of RBEL1A research with future research directions and challenges.

Research on Rab-like protein 1A (RBEL1A) in the past two decades highlighted the oncogenic properties of this gene. Despite the emerging evidence, its importance in cancer biology was underrated. This is the first RBEL1A critical review covering its discovery, biochemistry, physiological functions, and clinical insights.

Characterizations for the photothermal effect of Rhodamine 6G using white-light interferometry and windowed Fourier transform.

Photothermal phenomenon is one of the natural responses in light-matter interactions in which the energy of the incident light is converted into heat, resulting in a temperature increase in the illuminated material. This effect has a direct influence on the refractive index of the material such that its change of spectral dependency with temperature can be exploited for different applications. However, it is also important to separate/identify the thermal effect from the optical/electronic resonance effect to expand potential applications of light-matter interactions.

A small molecule M1 promotes optic nerve regeneration to restore target-specific neural activity and visual function.

Axon regeneration is an energy-demanding process that requires active mitochondrial transport. In contrast to the central nervous system (CNS), axonal mitochondrial transport in regenerating axons of the peripheral nervous system (PNS) increases within hours and sustains for weeks after injury. Yet, little is known about targeting mitochondria in nervous system repair.

Jones-matrix imaging based on two-photon interference.

Two-photon interference is an important effect that is tightly related to the quantum nature of light. Recently, it has been shown that the photon bunching from the Hong-Ou-Mandel (HOM) effect can be used for quantum imaging in which sample properties (reflection/transmission amplitude, phase delay, or polarization) can be characterized at the pixel-by-pixel level. In this work, we perform Jones matrix imaging for an unknown object based on two-photon interference.

Sodalis ligni Strain 159R Isolated from an Anaerobic Lignin-Degrading Consortium.

Novel bacterial isolates with the capabilities of lignin depolymerization, catabolism, or both, could be pertinent to lignocellulosic biofuel applications. In this study, we aimed to identify anaerobic bacteria that could address the economic challenges faced with microbial-mediated biotechnologies, such as the need for aeration and mixing. Using a consortium seeded from temperate forest soil and enriched under anoxic conditions with organosolv lignin as the sole carbon source, we successfully isolated a novel bacterium, designated 159R.

Polarization coincidence images from metasurfaces with HOM-type interference.

Metasurfaces provide a promising route for structuring light and generating holograms with designed amplitude, phase, and polarization profiles, leading to a versatile platform for integrating and constructing optical components beyond the conventional ones. At the same time, incorporating coincidence in imaging allows a high signal-to-noise ratio for imaging in very low light levels. As beneficial from the recent development in both metasurfaces and single-photon avalanche diode (SPAD) cameras, we combine the polarization-sensitive capability of metasurfaces with Hong-Ou-Mandel (HOM)-type interference in generating images with tailor-made two-photon interference and polarization coincidence signatures.

Controlling asymmetric transmission phase in planar chiral metasurfaces.

Metasurfaces with ultrathin artificial structures have attracted much attention because of their unprecedented capability in light manipulations. The recent development of metasurfaces with controllable responses opens up new opportunities in various applications. Moreover, metasurfaces composed of twisted chiral structures can generate asymmetric responses for opposite incidence, leading to more degrees of freedom in wave detections and controls.

Tailor-made unitary operations using dielectric metasurfaces.

Qubit operation belonging to unitary transformation is the fundamental operation to realize quantum computing and information processing. Here, we show that the complex and flexible light-matter interaction between dielectric metasurfaces and incident light can be used to perform arbitrary U(2) operations. By incorporating both coherent spatial-mode operation together with two polarizations on a single metasurface, we further extend the discussion to single-photon two-qubit U(4) operations.

In Search of Molecular Markers for Cerebellar Neurons.

The cerebellum, the region of the brain primarily responsible for motor coordination and balance, also contributes to non-motor functions, such as cognition, speech, and language comprehension. Maldevelopment and dysfunction of the cerebellum lead to cerebellar ataxia and may even be associated with autism, depression, and cognitive deficits. Hence, normal development of the cerebellum and its neuronal circuitry is critical for the cerebellum to function properly.

Quantitative measurement and mechanism analysis of the high-efficiency laser propulsion of a graphene sponge.

Laser propulsion of a graphene sponge shows tremendous potential in propellant-free flight, photoresponsive actuators and micro opto-electro mechanical systems. However, the mechanism is still in dispute and the propulsion force hasn't been accurately measured, seriously hindering its development. This work develops a quantitative method to measure the propulsion force.

Phenotypic characteristics of commonly used inbred mouse strains.

The laboratory mouse is the most commonly used mammalian model for biomedical research. An enormous number of mouse models, such as gene knockout, knockin, and overexpression transgenic mice, have been created over the years. A common practice to maintain a genetically modified mouse line is backcrossing with standard inbred mice over several generations.

Circular Phase-Dichroism of Chiral Metasurface Using Birefringent Interference.

Circular phase-dichroism (CPD) has been suggested for the characterization of chiral metasurfaces in supplementing the conventional circular dichroism (CD). Conventional CD probes the bulk properties while the CPD, reported recently in 2D chiral metasurfaces using an air-gap Fabry-Perot setup, is based on the surface properties. Here we propose and demonstrate a robust birefringent interference approach to obtain the CPD by replacing the air-gap with a uniaxial birefringent material in which interference is realized by the difference in the refractive indexes for the ordinary and extraordinary components of the material.

Exceptional point-based plasmonic metasurfaces for vortex beam generation.

An exceptional point occurring in a tailor-made lossy optical system has been recently found to alter optical properties in counter-intuitive ways. In the context of tunable plasmonic devices, exceptional points can be useful as a driving mechanism to enhance tunability. Here, we experimentally demonstrate how a plasmonic exceptional point can be incorporated in metasurface Q-plates to have the generated vortex beam tuned through a change of structural parameter.

Characterization of free-standing 1D photonic crystals using an effective medium approach.

Photonic crystals (PCs) are usually fabricated on bulk substrates which break the symmetry of the PC system for incidence from either side of the PCs. Here we report the fabrication of a free-standing 1D layered dielectric PC by using a two-beam holographic interference method. The free-standing PC exhibits distinct photonic bandgaps as well as Fabry-Perot oscillations in the photonic bands.

Characterization of thermal bump due to surface plasmon resonance.

Surface plasmon resonance (SPR) has found wide applications in sensing down to molecular level due to its extreme sensitivity to change of dielectric properties. An unavoidable effect in SPR is surface deformation (thermal bump) due to local heating by incident laser light used in SPR. In addition, changes in the reflection phase from the metal film used in SPR could also contribute to the SPR signal, and thus proper handling of the SPR signal is very important in order to broaden the potential applications of SPR.

Complete Genome Sequence of Serratia quinivorans Strain 124R, a Facultative Anaerobe Isolated on Organosolv Lignin as a Sole Carbon Source.

The complete genome sequence of the gammaproteobacterial isolate 124R consists of 5 Mb over 2 scaffolds and a G+C content of 52.85%. Genes relating to aromatic metabolism reflect its isolation on organosolv lignin as a sole carbon source under anoxic conditions as well as the potential for lignin biorefinery applications.

Experimental demonstration of angular momentum-dependent topological transport using a transmission line network.

Novel classical wave phenomenon analogs of the quantum spin Hall effect are mostly based on the construction of pseudo-spins. Here we show that the non-trivial topology of a system can also be realized using orbital angular momentum through a coupling between the angular momentum and the wave vector. The idea is illustrated with a tight-binding model and experimentally demonstrated with a transmission line network.

Three dimensional chiral plasmon rulers based on silver nanorod trimers.

The symmetry dependences of plasmon excitation modes are studied in 3D silver nanorod trimers. The degenerate plasmon modes split into chiral modes by breaking the inversion and mirror symmetry of the nanorod trimer through translation and/or rotation of the middle rod. With a translation operation, successive evolution of the circular dichroism (CD) spectrum can be achieved through gradual breaking of the inversion symmetry.

Correction of numerical aperture effect on reflection phase measurement using a thick-gap Fabry-Perot etalon.

We propose a method for the measurement of the reflection phase using a thick-gap Fabry-Perot (FP) etalon interferometry technique with correction for the numerical aperture effect of the optical setup. The setup is first calibrated using a known sample by comparing the reflectance from a two-beam interference model for the FP etalon with experimental data. We then apply the correction to a sample of interest and obtain the reflection phase of the sample.

Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin.

In the cerebellar cortex, Purkinje cells (PCs) receive signals from different inputs through their extensively branched dendrites and serve as an integration centre. Defects in the dendritic development of PCs thus disrupt cerebellar circuitry and cause ataxia. Here we report that specific inactivation of both Lhx1 and Lhx5 in postnatal PCs results in ataxic mutant mice with abnormal dendritic development.

Controlling interface states in 1D photonic crystals by tuning bulk geometric phases.

There is no known simple rule that assures the existence of interface states in photonic crystals (PCs). We show here that one can control the existence or absence of interface states in 1D PCs through engineering the bulk geometrical phase such that interface states can be guaranteed in some or all photonic bandgaps. We verify experimentally the interface state design paradigm in 1D multilayered PCs fabricated by electron beam vapor deposition.

Measurement of reflection phase using thick-gap Fabry-Perot etalon.

We report measurement of the reflection phase of a dielectric (glass)/titanium (Ti) surface in the visible wavelength using a thick-gap Fabry-Perot (FP) interferometry technique. Using a two-beam interference model for the reflection peaks and troughs of the FP etalon, we obtain the air-gap spacing of the etalon and, more importantly, the reflection phase of the etalon substrate. We find systematic dependence of the as-measured reflection phase on the air-gap spacing due to the numerical aperture effect of the measuring objective.