Publications by authors named "Wing K Man"
Article Synopsis
- A study was conducted in the Netherlands to analyze the genetic differences between Group B Streptococcus (GBS) causing neonatal disease and those found in healthy mothers, using whole genome sequencing on 1,418 isolates.
- It was found that specific genotypes, particularly Clonal Complex 17 and serotype III, were more prevalent in disease cases, while maternal isolates showed other serotypes like II, IV, V and CC1.
- The findings indicate that certain GBS genotypes are consistently linked to invasive neonate disease, suggesting targeted screening could improve prevention, while mobile genetic elements are tied to the broader GBS population's expansion rather than specific disease outcomes.
Objectives: We aimed to determine diagnostic accuracy of inflammatory markers in plasma and cerebrospinal fluid (CSF) for the diagnosis of central nervous system (CNS) infections and specifically bacterial meningitis.
Methods: We analyzed 12 cytokines, chemokines, and acute phase reactants in CSF and plasma of 738 patients with suspected neurological infection included in a multicenter prospective cohort. We determined diagnostic accuracy for predicting any CNS infection and bacterial meningitis.
Background: Development of neurodegeneration in older people has been associated with microglial cell activation triggered by systemic infection. We hypothesize that α7 nicotinic acetylcholine receptor (α7nAChR) plays an important role in regulation of this process.
Methods: 8- to 10-week-old male wild-type (WT) and α7nAChR knock-out (α7nAChR) mice were intraperitoneally inoculated with live Escherichia (E.
α-Synuclein (αS) is a presynaptic disordered protein whose aberrant aggregation is associated with Parkinson's disease. The functional role of αS is still debated, although it has been involved in the regulation of neurotransmitter release via the interaction with synaptic vesicles (SVs). We report here a detailed characterisation of the conformational properties of αS bound to the inner and outer leaflets of the presynaptic plasma membrane (PM), using small unilamellar vesicles.
View Article and Find Full Text PDFα-Synuclein (αS) is a presynaptic protein whose aggregation is associated with Parkinson's disease (PD). Although the physiological function of αS is still unclear, several lines of evidence indicate that this protein may play a role in the trafficking of synaptic vesicles (SVs) during neurotransmitter release, a task associated with its ability to bind SVs and promote their clustering. It is therefore crucial to identify the cellular factors that modulate this process.
View Article and Find Full Text PDFCharacterization of a Listeria monocytogenes meningitis mouse model.
J Neuroinflammation
September 2018
Background: Listeria monocytogenes is a common cause of bacterial meningitis. We developed an animal model of listerial meningitis.
Methods: In survival studies, C57BL/6 mice received intracisternal injections with different L.
Objectives: We report on the incidence, clinical characteristics, and bacterial genotype of group A streptococcal (GAS) meningitis in the Netherlands.
Methods: We assessed the incidence, clinical characteristics, and outcome of patients with GAS meningitis from a nationwide cohort study of adults with community-acquired bacterial meningitis in the Netherlands from 2006 to 2013.
Results: GAS was identified in 26 of 1322 patients with community-acquired bacterial meningitis (2%); 9 cases (35%) occurred in the first four months of 2013.