Publications by authors named "Winfried Rosen"
Article Synopsis
- Actinoplanes sp. SE50/110 is the wild type strain responsible for producing acarbose, a treatment for type II diabetes.
- The small protein Cgt, found in this strain, binds to starch and is repressed by glucose or lactose, suggesting a role in sugar metabolism or stress protection.
- However, when Cgt was deleted using CRISPR/Cas9, it showed no significant impact on stress response or carbon source utilization, but interestingly, strains with Cgt deletion produced 8-16% more acarbose in maltose-rich environments.
Background: Actinoplanes sp. SE50/110 is a natural producer of acarbose. It has been extensively studied in the last decades, which has led to the comprehensive analysis of the whole genome, transcriptome and proteome.
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