Notch expression profile and satellite cell stimulation in masseter muscle before and after orthognathic surgery.

The aim of this prospective study was to compare the expression of the Notch receptor family with the biomarker for stimulation of satellite cells (SC), which are responsible for functional adaptation. Tissue samples from the masseter muscle were taken presurgically and 7 months later. Samples from controls came from the extraction of third molars.

Satellite cell capacity for functional adaptation of masseter muscle in Class II and Class III patients after orthognathic surgery-a pilot study.

Aim: The aim of the prospective pilot study was to analyze the biomarkers CD34, Pax7, Myf5, and MyoD for stimulation of satellite cells (SCs), which are responsible for functional adaptation.

Subjects And Methods: Forty-five Caucasian patients were consecutively recruited from the Maxillo-Facial-Surgery at TU Dresden. Eleven orthognathic Class III patients, 24 Class II patients, and 10 controls with Class I were involved in the study.

Long term skeletal and dental changes between tooth-anchored versus Dresden bone-anchored rapid maxillary expansion using CBCT images in adolescents: Randomized clinical trial.

Objective: The aim of this study was to determine long-term skeletal and dental changes in tooth-anchored versus Dresden bone-anchored rapid maxillary expansion using CBCT images in adolescents.

Materials And Methods: In all, 29 adolescent patients (11-17 years of age) needing skeletal expansion were randomly allocated to two different groups treated by either a Dresden bone-anchored expander or a conventional hyrax expander. Patients included did not have previous orthodontic treatment, were non-syndromic and had all teeth present in mouth.

Transverse, vertical, and anterior-posterior changes between tooth-anchored versus Dresden bone-anchored rapid maxillary expansion 6 months post-expansion: A CBCT randomized controlled clinical trial.

Objective: The main aim of this randomized clinical trial was to determine 3 dimensional skeletal and dental changes six months after the use of bone-anchored versus tooth-anchored rapid maxillary expanders in adolescents. The secondary aim was to determine the symmetrical or asymmetrical expansion pattern between both appliances.

Materials And Methods: Fifty adolescents with skeletally constricted maxilla (mean age 13-14 years) were randomly assigned into: Dresden B-RME, Hyrax T-RME, or untreated control groups.

Predictive values of resonance frequency analysis as a diagnostic tool in palatal implant loss.

Objectives: To determine the diagnostic value of resonance frequency analysis (RFA) in predicting palatal implant (PI) loss

Materials And Methods: RFA values of 32 patients (study center at Mainz and Dresden) were evaluated in a prospective randomized controlled trial addressing clinical performance of two loading concepts on PI (Orthosystem, Straumann, Basel, Switzerland). Group 1: conventional loading after a 12-week healing period vs group 2: immediate loading within one week after insertion. Stability was assessed by RFA after surgical insertion (T1), one week (T2), and 12 weeks (T3) later.

Genetic response in masseter muscle after orthognathic surgery in comparison with healthy controls - A Microarray study.

One third of adult patients with orthognathic surgery of a prognathic or retrognathic mandible show relapse. The sagittal split osteotomy of the mandible leads to a displacement of both parts up to 10 mm without any changes of muscle attachment. Changed mandible length needs adaptation of muscle capacity because of changed force to moment ratio.

A ³¹P-magnet resonance spectroscopy study on the metabolism of human masseter in individuals with different vertical facial pattern.

Objective: The objective of this study was to investigate differences in masseter metabolism by (31)P-Chemical Shift Imaging (CSI) in adult individuals with different vertical facial patterns. The clinical study should be supported by functional findings at the mRNA level after orthognathic surgery.

Study Design: Twenty-two male volunteers (mean age 24.

Genetic stretching factors in masseter muscle after orthognathic surgery.

Up to 30% of patients relapse after orthognathic operations, and one reason might be incomplete neuromuscular adaptation of the masticatory muscles. Displacement of the mandible in sagittal or vertical directions, or both, leads to stretching or compression of these muscles. The aim of this study was to analyse stretching factors in 35 patients with retrognathism or prognathism of the mandible (Classes II and III).

Bone density of the midpalatal suture 7 months after surgically assisted rapid palatal expansion in adults.

Introduction: The aims of this study were to analyze changes in bone density of the midpalatal suture after surgically assisted rapid palatal expansion (SARPE) with the bone-borne Dresden Distractor (DD; ITU, Dresden, Germany) via computed tomography (CT) and to compare of preoperative surgical findings with a control group.

Methods: Sixteen adult patients (mean age 24.5 years) underwent axial CT scans before and 7 months after SARPE.

Shear bond strength after multiple bracket bonding with or without repeated etching.

The purpose of the study was to measure the in vitro shear bond strength (SBS) of metal brackets after multiple bonding and debonding with and without repeated etching. One hundred and twenty extracted premolars were divided into three equal groups. In group 1, the brackets were bonded and debonded three times with repeated enamel etching and in groups 2 and 3 without repeated etching.

Changes in nasal volume after surgically assisted bone-borne rapid maxillary expansion.

Introduction: The purposes of this study were to detect, locate, and examine the changes in transverse nasal width, area, and volume from bone-borne, surgically assisted rapid maxillary expansion (SARME) with the Dresden distractor by using computer tomography (CT).

Methods: Sixteen patients (average age, 28.7 years) underwent axial CT scanning before and 6 months after SARME.

Spectrum of indications for palatal implants in treatment concepts involving immediate and conventional loading.

Aim: To analyze the spectrum of indications for second-generation palatal implants in relation to two different loading concepts in a prospective, multicenter, randomized controlled trial (RCT).

Patients And Methods: Forty-one patients were recruited to the study from 2006 to 2009. All implants (Orthosystem, Straumann, Basel, Switzerland; dimensions: 4.

Developmental myosin heavy chain mRNA in masseter after orthognathic surgery: a preliminary study.

Introduction: A microarray study showed an increase of developmental myosin heavy chain (MyHC) mRNA in the masseter muscle after surgery. The aim of the study was to determine the expression of the embryonic MYH3 and perinatal MYH8 for use as potential marker for muscle adaptation after orthognathic surgery.

Material And Methods: 24 adult patients with a prognathic (11) or retrognathic (13) mandible were involved in the study.

Immediate versus conventional loading of palatal implants in humans: a first report of a multicenter RCT.

This study aims to analyze the clinical performance of two loading concepts on second-generation palatal implants (Orthosystem, Straumann, Basel, Switzerland) in a prospective multicenter randomized controlled clinical trial. At the time of this interim analysis, 41 patients have been randomized on a 1:1 basis to one of two treatment groups. Group 1 underwent conventional loading of palatal implants after a healing period of 12 weeks (gold standard) while group 2 underwent immediate implant loading within 1 week after implant insertion.

Minimally invasive rapid palatal expansion with an implant-supported hyrax screw.

Rapid palatal expansion is indicated in the orthopedic treatment of transverse maxillary deficiency for correction of severe crossbite. The fixation of the appliance at the tooth crowns leads to more tipping connected with resorptions at the buccal cortical bone, fenestrations and gingival retraction. The aim of the present study was focused on the improvement of bodily movement and optimization of the surgical osteotomy (Glassman's technique) in adult patients with application of the Dresden Distractor (DD).

CT analysis of nasal volume changes after surgically-assisted rapid maxillary expansion.

Objective: Aim of this study was to detect the changes in nasal volume due to bone-borne, surgically-assisted rapid palatal expansion (RPE) with the Dresden Distractor using computed tomography (CT).

Materials And Methods: 17 patients (mean age 28.8) underwent axial CT scanning before and 6 months after RPE.

Incisor inclination--risk factor for palatally-impacted canines.

Objective: The purpose of this study was to evaluate the torque of upper incisors and the maxillary size in sagittal direction in patients with impacted canines.

Material And Methods: Panoramic radiographs, cephalograms and pretreatment study models were evaluated in 199 patients (12.7 +/- 3.

Autotransplantation of first premolar to replace a maxillary incisor - 3D-volume tomography for evaluation of the periodontal space.

Unlabelled: The anterior maxilla is the most traumatized region during childhood and tooth loss is frequently involved. Space closure with implants is contraindicated in growing patients and maintenance of space is necessary over a long period. Transplantation of premolars from the mandible with two-third to three-quarter root formation wide open foramen provides the best prognosis for permanent survival.

MGF- and myostatin-mRNA regulation in masseter muscle after orthognathic surgery.

Patients with prognathism and retrognathism show extensive morphologic changes after orthognathic surgery. The inability of muscles to adapt adequately might be one reason for observed relapses. The aim of this prospective study was to analyze the regulation of functional genes after surgery and changes in myosin heavy chain (MyHC) isoform expression, a potential molecular marker profile for inadequate muscle adaptation.

[Bone-supported rapid maxillary expansion with an implant-borne Hyrax screw: the Dresden Distractor].

Rapid palatal expansion is indicated in the orthopedic treatment of transverse maxillary deficiency for correction of severe crossbite. The fixation of the appliance at the teeth crowns leads to more tipping at the two halves of the maxilla than bodily transverse movement. Additional resorptions at the buccal cortical bone with fenestrations and gingival retraction were observed.

Treatment of a patient with Class II malocclusion, impacted maxillary canine with a dilacerated root, and peg-shaped lateral incisors.

The maxillary canines are important teeth in terms of esthetics and function. This case report describes the orthodontic treatment of a 12-year-old girl whose Class II malocclusion was complicated by an impacted maxillary canine and peg-shaped lateral incisors. Despite dilaceration of the root, the impacted canine was brought into alignment.

Early loading of plalatal implants (ortho-type II) a prospective multicenter randomized controlled clinical trial.

Background: In orthodontic treatment, anchorage control is a fundamental aspect. Usually conventional mechanism for orthodontic anchorage control can be either extraoral or intraoral that is headgear or intermaxillary elastics. Their use are combined with various side effects such as tipping of occlusal plane or undesirable movements of teeth.

Histological and histomorphometric investigation of the condylar cartilage of juvenile pigs after anterior mandibular displacement.

The condylar cartilage of the mandible is considered a secondary growth center and represents a joint cartilage different from other cartilage structures regarding its histological structure, its histochemical and immunohistochemical properties and its growth pattern. This study aimed to histologically and histomorphometrically investigate the condylar cartilage after anterior mandibular displacement similar to functional orthopedic treatment. A total of 12 pigs (sus scrofa domesticus) aged 10 weeks were divided into an experimental group and a control group comprising 6 animals each.

Myosin heavy chain mRNA isoforms in masseter muscle before and after orthognathic surgery.

Objectives: Orthognathic surgery leads to changed jaw position and force vector of mastication to which the muscles must adapt. The aim of the present study was to determine the relative expression of myosin heavy chain (MyHC) messenger RNA (mRNA) isoforms in different types of human masseter muscle fiber under consideration of change in the number of occlusal contacts before and 6 months after surgery.

Study Design: Muscle biopsies were taken from the anterior and posterior parts of both sides in 30 patients with prognathic and retrognathic mandibles.

Effects of unilateral molar distalization with a modified pendulum appliance.

Introduction: The purpose of this study was to evaluate skeletal and dentoalveolar changes due to unilateral distalization and to determine side effects.

Methods: Cephalograms and dental casts before and after distal movement of the maxillary molars with pendulum appliances in 15 consecutively treated patients (5 girls and 10 boys, 12.06 +/- 1.