Publications by authors named "Winfred T Frazier"
The minority tax has been defined as a set of disparities that those who are underrepresented in medicine face in addition to clinical care, education, and research responsibilities. These taxes include systemic racism, diversity efforts, clinical and promotion disparities, lack of faculty development, and isolation. Much has been added to the literature to better define and characterize the minority tax and propose suggestions for mitigations.
View Article and Find Full Text PDFBackground: Topical corticosteroids are widely used as a treatment for itch and wheals (urticaria), but their benefits and harms are unclear.
Objective: To systematically synthesize the benefits and harms of topical corticosteroids for the treatment of urticaria.
Methods: We searched MEDLINE, EMBASE, and CENTRAL from database inception to March 23, 2024, for randomized trials comparing topical corticosteroids with placebo for patients with urticaria (either chronic spontaneous or inducible urticaria or acute urticaria elicited from skin/intradermal allergy testing).
Article Synopsis
- The American Academy of Allergy, Asthma, and Immunology is updating its guidelines for managing atopic dermatitis (AD) due to advancements in treatment and evidence methods since the last update in 2012.
- A multidisciplinary panel, including AD specialists and patient representatives, created evidence-based guidelines emphasizing equity, diversity, and minimizing conflicts of interest while reviewing systematic evidence.
- The panel produced 25 recommendations to help manage AD and included practical implementation resources for patients, covering various treatment options like topical corticosteroids, calcineurin inhibitors, and more.
Article Synopsis
- Atopic dermatitis (AD) is a skin condition that causes inflammation and can be treated in different ways, but it's not always clear which treatments work best.
- Researchers looked at many studies to compare the benefits and risks of different treatments for AD.
- They found that some treatments, like high-dose upadacitinib, were very effective but also had more side effects, while others like dupilumab were safer but less powerful.
Article Synopsis
- Atopic dermatitis (AD) is a widespread skin condition treated with various topical prescriptions, but their comparative effectiveness is not well known.
- A systematic review of randomized trials was conducted to evaluate the benefits and harms of topical treatments for AD, employing rigorous analysis and classification methods.
- High-certainty evidence showed that pimecrolimus and high-dose tacrolimus were highly effective, while group 5 topical corticosteroids (TCS) also significantly aided in managing AD without increasing harm.
Article Synopsis
- The study aims to synthesize patient and caregiver values and preferences in managing atopic dermatitis (AD) to aid the development of clinical guidelines by relevant allergy associations.* ! -
- A thorough review of numerous studies revealed that participants generally favor starting with nonmedical treatments and are concerned about side effects from medications, highlighting the importance of a strong patient-clinician relationship.* ! -
- Findings indicate that patients prefer treatments that are odorless, minimally visible, and have a low impact on daily activities, with a specific emphasis on relieving itching and burning sensations.* !
Article Synopsis
- Individuals with skin of color come from various racial and ethnic backgrounds, such as Black, Asian, Hispanic, and Middle Eastern, and face specific dermatologic health disparities due to systemic racism and insufficient physician training.
- Common skin conditions affecting these populations include postinflammatory hyperpigmentation, keloids, and pseudofolliculitis barbae, which are often underdiagnosed and can significantly impact mental health and quality of life.
- Treatments vary by condition, with hydroquinone 4% as the standard for postinflammatory hyperpigmentation, keloid treatments involving triamcinolone and fluorouracil, and specific measures for pseudofolliculitis barbae like shaving cessation.
Article Synopsis
- Atopic dermatitis (AD) is influenced by skin barrier issues, immune responses, and factors like allergens, but the specific role of environmental allergens in aggravating AD is not well understood.
- A study reviewed 23 randomized controlled trials to assess the benefits and harms of allergen immunotherapy (AIT) like subcutaneous (SCIT) and sublingual (SLIT) therapies for easing AD symptoms and improving quality of life (QoL).
- Results indicated that both SCIT and SLIT significantly improve AD severity and QoL but also lead to more adverse events, suggesting that while they can help manage symptoms, there are trade-offs to consider.
Onychomycosis is a chronic fungal infection of the fingernail or toenail bed leading to brittle, discolored, and thickened nails. Onychomycosis is not just a cosmetic problem. Untreated onychomycosis can cause pain, discomfort, and physical impairment, negatively impacting quality of life.
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