Characterization of outcomes in patients with advanced genitourinary malignancies treated with immune checkpoint inhibitors.

Purpose: Several immune checkpoint inhibitors (ICIs) are FDA approved for treatment of genitourinary (GU) malignancies. We aim to determine demographic and clinicopathologic characteristics that significantly affect clinical outcomes in patients with advanced stage GU malignancies treated with ICIs.

Materials And Methods: We performed a single-center, consecutive, retrospective cohort analysis on patients with metastatic or unresectable GU malignancies who were treated with ICIs at the University of Michigan.

"Live, Learn and Play": building strategic alliances between professional sports and public health.

Public-private partnerships allow communities and corporate entities to pool resources to address a mission of relevance to their common constituency or consumer base. Collaborations between public health and professional sports may present unique opportunities to improve health outcomes related to physical activity since athletes are fitness icons, both for adults and children. There are many "win-win" opportunities, as sports venues regularly host huge numbers of spectators, offering food and entertainment, providing hours of exposure, and introducing new ideas for engaging fans in order to remain a competitive draw.

Time perspective as a potential tool for psychotherapeutic intervention.

This pilot study shows (1) similarities among adults in the patterns of organization of the past, present, and future based upon individual imagery and spatial representation of their personal perspective of their lives and (2) a relationship between perceived health and future-orientation, i.e., how far into their future a person imagines self still to be alive.

Audit of bone marrow aspirates and trephine biopsies in multiple myeloma--a single centre study.

We compared 79 simultaneous marrow aspirates and trephine biopsies from multiple myeloma patients for sensitivity, concordance, quality and clinical relevance. A total of 60 examinations had been performed for initial diagnosis, i.e.

Pityocampal erucism in a British serviceman in Croatia--a case report.

We present a case of erucism (caterpillar dermatitis) in a British serviceman deployed in Croatia on Operation Resolute. The aetiology, clinical features and diagnosis of erucism are discussed. Erucism should be highlighted as an environmental hazard in future troop deployments to the Mediterranean area.

Autoimmune thrombocytopenia: a complication of fludarabine therapy in lymphoproliferative disorders.

We describe two cases of autoimmune thrombocytopenia precipitated by fludarabine therapy in patients with chronic lymphatic leukaemia. Both were treated with high dose steroids and initially responded with recovery of normal platelet counts. One patient developed recurrent autoimmune thrombocytopenia on two occasions following re-exposure to the drug when his disease had become refractory to all other treatments.

Scrotal ulceration during all-trans retinoic (ATRA) therapy for acute promyelocytic leukaemia.

We report the development of painful scrotal ulceration in two patients during treatment with all-trans-retinoic acid (ATRA) for acute promyelocytic leukaemia (APL). ATRA 45 mg/m2 was administered orally for 8 days prior to the addition of standard induction chemotherapy. Painful scrotal ulceration developed in both cases within 2 weeks of therapy (9 and 13 days) and responded slowly to drug withdrawal and systemic, or topical, corticosteroids.

Fatal cold anti-i autoimmune haemolytic anaemia complicating hairy cell leukaemia.

Hairy cell leukaemia (HCL) is a rare lymphoproliferative disorder associated with pancytopenia, splenomegaly and the presence of typical hairy B lymphocytes in the bone marrow and/or peripheral blood. The most significant complication relates to opportunistic infections that arise as a consequence of neutropenia and monocytopenia. HCL is occasionally associated with systemic autoimmune disorders including polyarteritis nodosa and rheumatoid disease.

Automated exchange transfusion for life-threatening plasmodium falciparum malaria--lessons relating to prophylaxis and treatment.

We report a case of traveller to Kenya who contracted severe plasmodium falciparum malaria complicated by disseminated intravascular coagulation and acute renal failure. She had taken no antimalarial prophylaxis in view of concerns in the media regarding the adverse effects of mefloquine. There was a protracted delay before the diagnosis of malaria was made.

High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML.

Hodgkin's disease is curable in the majority of patients, although a proportion of patients are resistant to or relapse after initial therapy. High-dose therapy with autologous stem cell support has become the standard salvage therapy for patients failing chemotherapy, but there have been reports of a high incidence of myelodysplasia/acute myeloid leukaemia (MDS/AML) following such treatment. Patients who receive such therapy form a selected group, however, who have already been subjected to other leukaemogenic factors, such as treatment with alkylating agents.

Phase III efficacy study of interleukin-3 after autologous bone marrow transplantation in patients with malignant lymphoma.

We evaluated the efficacy of recombinant human interleukin-3 (rhIL-3) in reducing the number of platelet transfusions and major infections after autologous bone marrow transplantation (ABMT) in patients with malignant lymphoma. 198 patients with non-Hodgkin's lymphoma (NHL, n = 111) and Hodgkin's disease (HD, n = 87) were randomized to receive rhIL-3 10 microgram/kg/d (n = 130) or placebo (n = 68) for a maximum of 28 d after ABMT. Several well-known conditioning regimens were used.

Aircrew lumbar supports: an update.

The numbers and types of aircraft flown by aircrew being issued with lumbar supports at the Aviation Medicine Training Centre (AMTC), Royal Air Force Henlow, has been examined for the year 1997. A total of 67 lumbar supports were issued, 46% to the Army, 37% to the RAF and 15% to the Royal Navy. Rotary wing aircraft constituted the majority of issues (73%) compared with fixed wing aircraft (27%); the Gazelle formed the highest component (34%), followed by the Lynx (20%) and the Sea King (14%).

Efficacy of urate oxidase (uricozyme) in tumour lysis induced urate nephropathy.

Urate oxidase (uricozyme) is an enzyme of non-human origin capable of oxidizing human uric acid to allantoin, a highly soluble product at renal tubule pH. We report its efficacy in three patients with acute urate nephropathy due to tumour lysis in chronic lymphatic leukaemia and high grade lymphoma. Two patients had an additional obstructive nephropathy due to ureteric urate crystals.

Evidence-based well-baby care. Part 2: Education and advice section of the next generation of the Rourke Baby Record.

Problem Being Addressed: Well baby and child care in the primary care setting has not always been based on evidence that has been shown to be effective in preventing and detecting disease and injury.

Objective Of The Program: To help physicians and nurses provide care that is more effective than a routine complete examination, the Rourke Baby Record has been revised to include evidence-based recommendations for preventive care for infants and young children. The revision incorporates the approach and recommendations of the Canadian Task Force on the Periodic Health Examination.

Evidence-based well-baby care. Part 1: Overview of the next generation of the Rourke Baby Record.

Problem Being Addressed: Well baby and child care in the primary care setting has not always been based on evidence that has been shown to be effective in preventing and detecting disease and injury.

Objective Of The Program: To help physicians and nurses provide care that is more effective than a routine complete examination, the Rourke Baby Record has been revised to include evidence-based recommendations for preventive care for infants and young children. The revision incorporates the approach and recommendations of the Canadian Task Force on the Periodic Health Examination.

G-CSF after peripheral blood stem cell transplantation in lymphoma patients significantly accelerated neutrophil recovery and shortened time in hospital: results of a randomized BNLI trial.

We have undertaken a prospective randomized study in 90 patients with relapsed or resistant lymphomas to assess the value of G-CSF (lenograstim) in the acceleration of myeloid recovery after peripheral blood stem cell transplantation (PBSCT). A common regimen of cyclophosphamide 1.5 g/m2 on day 1 and lenograstim 263 microg s.

Aerospace technology transfer to breast cancer imaging.

In the United States in 1996, an estimated 44,560 women died of breast cancer, and 184,300 new cases were diagnosed. Advances in space technology are now making significant improvements in the imaging technologies used in managing this important foe. The first of these spinoffs, a digital spot mammography system used to perform stereotactic fine-needle breast biopsy, uses a backside-thinned CCD developed originally for the Space Telescope Imaging Spectrometer.

Mental health problems on Operation Resolute (Bosnia).

Mental health problems have been studied in a total of 2201 consultations with British troops in a primary health care practice on Operation Resolute (Bosnia) from 1 January to 31 March 1996. About one in 40 (2.5%) of the consultations were for mental health problems; Post Traumatic Stress Disorder (PTSD), depressive disorder, and grief reaction were the most common disorders, followed by acute adjustment reaction and panic disorder.

An outbreak of rubella in British troops in Bosnia.

An outbreak of rubella in April 1996 involved four male British soldiers deployed to Bosnia-Herzegovina. All were helicopter ground crew who were members of the same unit and who periodically travelled to and worked at forward air refuelling stations in Bosnia. There was a potential for spread of the infection to adjacent British units, to troops of other nations in the peacekeeping force, and also to the local civilian population.

Dermatological conditions in winter in primary health care on Operation Resolute (Bosnia).

The distribution of dermatological conditions has been studied in a total of 1822 consultations with British troops in a primary health care setting on Operation Resolute (Bosnia) between 1 January and 4 March 1996. Approximately one in eight (12%) of the consultations were for skin conditions; eczema was the most common complaint, but, taken as a whole, infections due to virus (excluding warts), fungus and bacteria made up 30%. The overall distribution of diseases was similar to that seen in British general practice.

A study of primary health care at Divulje Barracks, Split on Operation Resolute (Bosnia).

A study of primary health care was undertaken at Divulje Barracks, Split, during Operation Resolute, 1996. A total of 1581 patients were seen during weeks 3 to 10 of the operation (day "13' to "70'). The number of consultations was greater for the first half of this period than for the second, and there were two early epidemics, one of respiratory disease and the other of enteric disease.