Publications by authors named "Wineland D"

^{133}Ba^{+} is illuminated by a laser that is far detuned from optical transitions, and the resulting spontaneous Raman scattering rate is measured. The observed scattering rate is lower than previous theoretical estimates. The majority of the discrepancy is explained by a more accurate treatment of the scattered photon density of states.

View Article and Find Full Text PDF

Purpose: Breast and ovarian tumors in germline carriers undergo allele-specific loss of heterozygosity, resulting in homologous recombination deficiency (HRD) and sensitivity to poly-ADP-ribose polymerase (PARP) inhibitors. This study investigated whether biallelic loss and HRD also occur in primary nonbreast/ovarian tumors that arise in germline carriers.

Methods: A clinically ascertained cohort of carriers with a primary nonbreast/ovarian cancer was identified, including canonical (prostate and pancreatic cancers) and noncanonical (all other) tumor types.

View Article and Find Full Text PDF

Prostaglandins (PGs), locally acting lipid signals, regulate female reproduction, including oocyte development. However, the cellular mechanisms of PG action remain largely unknown. One cellular target of PG signaling is the nucleolus.

View Article and Find Full Text PDF

Universal control of multiple qubits-the ability to entangle qubits and to perform arbitrary individual qubit operations-is a fundamental resource for quantum computing, simulation and networking. Qubits realized in trapped atomic ions have shown the highest-fidelity two-qubit entangling operations and single-qubit rotations so far. Universal control of trapped ion qubits has been separately demonstrated using tightly focused laser beams or by moving ions with respect to laser beams, but at lower fidelities.

View Article and Find Full Text PDF

We report high-fidelity state readout of a trapped ion qubit using a trap-integrated photon detector. We determine the hyperfine qubit state of a single ^{9}Be^{+} ion held in a surface-electrode rf ion trap by counting state-dependent ion fluorescence photons with a superconducting nanowire single-photon detector fabricated into the trap structure. The average readout fidelity is 0.

View Article and Find Full Text PDF

Scaling quantum information processors is a challenging task, requiring manipulation of a large number of qubits with high fidelity and a high degree of connectivity. For trapped ions, this can be realized in a 2D array of interconnected traps in which ions are separated, transported, and recombined to carry out quantum operations on small subsets of ions. Here, functionality of a junction connecting orthogonal linear segments in a 2D trap array to reorder a two-ion crystal is demonstrated.

View Article and Find Full Text PDF

A mixed-species geometric phase gate has been proposed for implementing quantum logic spectroscopy on trapped ions, which combines probe and information transfer from the spectroscopy to the logic ion in a single pulse. We experimentally realize this method, show how it can be applied as a technique for identifying transitions in currently intractable atoms or molecules, demonstrate its reduced temperature sensitivity, and observe quantum-enhanced frequency sensitivity when it is applied to multi-ion chains. Potential applications include improved readout of trapped-ion clocks and simplified error syndrome measurements for quantum error correction.

View Article and Find Full Text PDF

We present a general theory for laser-free entangling gates with trapped-ion hyperfine qubits, using either static or oscillating magnetic-field gradients combined with a pair of uniform microwave fields symmetrically detuned about the qubit frequency. By transforming into a 'bichromatic' interaction picture, we show that either or geometric phase gates can be performed. The gate basis is determined by selecting the microwave detuning.

View Article and Find Full Text PDF

We describe an optical atomic clock based on quantum-logic spectroscopy of the ^{1}S_{0}↔^{3}P_{0} transition in ^{27}Al^{+} with a systematic uncertainty of 9.4×10^{-19} and a frequency stability of 1.2×10^{-15}/sqrt[τ].

View Article and Find Full Text PDF

Special quantum states are used in metrology to achieve sensitivities below the limits established by classically behaving states. In bosonic interferometers, squeezed states, number states and 'Schrödinger cat' states have been implemented on various platforms and have demonstrated improved measurement precision over interferometers using coherent states. Another metrologically useful state is an equal superposition of two eigenstates with maximally different energies; this state ideally reaches the full interferometric sensitivity allowed by quantum mechanics.

View Article and Find Full Text PDF

Detection of the weakest forces in nature is aided by increasingly sensitive measurements of the motion of mechanical oscillators. However, the attainable knowledge of an oscillator's motion is limited by quantum fluctuations that exist even if the oscillator is in its lowest possible energy state. We demonstrate a technique for amplifying coherent displacements of a mechanical oscillator with initial magnitudes well below these zero-point fluctuations.

View Article and Find Full Text PDF

Large-scale quantum computers will require quantum gate operations between widely separated qubits. A method for implementing such operations, known as quantum gate teleportation (QGT), requires only local operations, classical communication, and shared entanglement. We demonstrate QGT in a scalable architecture by deterministically teleporting a controlled-NOT (CNOT) gate between two qubits in spatially separated locations in an ion trap.

View Article and Find Full Text PDF

We present a new method of spin-motion coupling for trapped ions using microwaves and a magnetic field gradient oscillating close to the ions' motional frequency. We demonstrate and characterize this coupling experimentally using a single ion in a surface-electrode trap that incorporates current-carrying electrodes to generate the microwave field and the oscillating magnetic field gradient. Using this method, we perform resolved-sideband cooling of a single motional mode to its ground state.

View Article and Find Full Text PDF

While nuclear actin was reported ~50 years ago, it's in vivo prevalence and structure remain largely unknown. Here, we use Drosophila oogenesis, that is, follicle development, to characterize nuclear actin. We find that three different reagents-DNase I, anti-actin C4, and anti-actin AC15-recognize distinct pools of nuclear actin.

View Article and Find Full Text PDF

We demonstrate superconducting nanowire single photon detectors with 76 ± 4% system detection efficiency at a wavelength of 315 nm and an operating temperature of 3.2 K, with a background count rate below 1 count per second at saturated detection efficiency. We propose integrating these detectors into planar surface electrode radio-frequency Paul traps for use in trapped ion quantum information processing.

View Article and Find Full Text PDF

We report correlation measurements on two ^{9}Be^{+} ions that violate a chained Bell inequality obeyed by any local-realistic theory. The correlations can be modeled as derived from a mixture of a local-realistic probabilistic distribution and a distribution that violates the inequality. A statistical framework is formulated to quantify the local-realistic fraction allowable in the observed distribution without the fair-sampling or independent-and-identical-distributions assumptions.

View Article and Find Full Text PDF

We report on Raman sideband cooling of ^{25}Mg^{+} to sympathetically cool the secular modes of motion in a ^{25}Mg^{+}-^{27}Al^{+} two-ion pair to near the three-dimensional (3D) ground state. The evolution of the Fock-state distribution during the cooling process is studied using a rate-equation simulation, and various heating sources that limit the efficiency of 3D sideband cooling in our system are discussed. We characterize the residual energy and heating rates of all of the secular modes of motion and estimate a secular motion time-dilation shift of -(1.

View Article and Find Full Text PDF

We apply laser fields to trapped atomic ions to constrain the quantum dynamics from a simultaneously applied global microwave field to an initial product state and a target entangled state. This approach comes under what has become known in the literature as "quantum Zeno dynamics" and we use it to prepare entangled states of two and three ions. With two trapped ^{9}Be^{+} ions, we obtain Bell state fidelities up to 0.

View Article and Find Full Text PDF

We report high-fidelity laser-beam-induced quantum logic gates on magnetic-field-insensitive qubits comprised of hyperfine states in ^{9}Be^{+} ions with a memory coherence time of more than 1 s. We demonstrate single-qubit gates with an error per gate of 3.8(1)×10^{-5}.

View Article and Find Full Text PDF

Precision control over hybrid physical systems at the quantum level is important for the realization of many quantum-based technologies. In the field of quantum information processing (QIP) and quantum networking, various proposals discuss the possibility of hybrid architectures where specific tasks are delegated to the most suitable subsystem. For example, in quantum networks, it may be advantageous to transfer information from a subsystem that has good memory properties to another subsystem that is more efficient at transporting information between nodes in the network.

View Article and Find Full Text PDF

A protocol is discussed for preparing a spin chain in a generic many-body state in the asymptotic limit of tailored nonunitary dynamics. The dynamics require the spectral resolution of the target state, optimized coherent pulses, engineered dissipation, and feedback. As an example, we discuss the preparation of an entangled antiferromagnetic state, and argue that the procedure can be applied to chains of trapped ions or Rydberg atoms.

View Article and Find Full Text PDF

We report large-mode-area solid-core photonic crystal fibers made from fused silica that resist ultraviolet (UV) solarization even at relatively high optical powers. Using a process of hydrogen loading and UV irradiation of the fibers, we demonstrate stable single-mode transmission over hundreds of hours for fiber output powers of 10 mW at 280 nm and 125 mW at 313 nm (limited only by the available laser power). Fiber attenuation ranges from 0.

View Article and Find Full Text PDF

Quantum simulation--the use of one quantum system to simulate a less controllable one--may provide an understanding of the many quantum systems which cannot be modelled using classical computers. Considerable progress in control and manipulation has been achieved for various quantum systems, but one of the remaining challenges is the implementation of scalable devices. In this regard, individual ions trapped in separate tunable potential wells are promising.

View Article and Find Full Text PDF

Entangled states are a key resource in fundamental quantum physics, quantum cryptography and quantum computation. Introduction of controlled unitary processes--quantum gates--to a quantum system has so far been the most widely used method to create entanglement deterministically. These processes require high-fidelity state preparation and minimization of the decoherence that inevitably arises from coupling between the system and the environment, and imperfect control of the system parameters.

View Article and Find Full Text PDF