Publications by authors named "Win-Ping Deng"

Phototherapy has been extensively used to prevent and treat signs of aging and stimulate wound healing, and phototherapy through light-emitting diodes (LEDs). In contrast to LED, organic LED (OLED) devices are composed of organic semiconductors that possess novel characteristics. We investigated the regenerative potential of OLED for restoring cellular potential from senescence and thus delaying animal aging.

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Background: -derived fucoidan, a multifunctional bioactive polysaccharide sourced from marine organisms, exhibits a wide range of therapeutic properties, including its anti-tumor effects. While previous research has reported on its anti-cancer potential, limited studies have explored its synergistic capabilities when combined with other natural bioactive ingredients. In this current study, we present the development of an integrative functional beverage, denoted as VMW-FC, which is composed of a fucoidan complex (FC) along with a blend of various herbal components, including vegetables (V), mulberries and fruits (M), and spelt wheat (W).

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Background: Bioactive materials have now raised considerable attention for the treatment of osteoarthritis (OA), such as knee OA, rheumatoid OA, and temporomandibular joint (TMJ) OA. TMJ-OA is a common disease associated with an imbalance of cartilage regeneration, tissue inflammation, and disability in mouth movement. Recently, biological materials or molecules have been developed for TMJ-OA therapy; however, ideal treatment is still lacking.

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Article Synopsis
  • The study investigates the link between dental scaling (DS) and the risk of spontaneous intracranial hemorrhage (ICH), finding that regular DS might lower the incidence of ICH compared to those who do not undergo DS.
  • In a cohort of over 681,000 subjects, those who received regular DS had a significantly lower ICH incidence (0.8%) compared to non-DS individuals (1.2%), with an adjusted hazard ratio of 0.61 for ICH risk.
  • The results suggest that individuals aged 30-39 who regularly underwent DS experienced the lowest ICH risk, indicating that DS may play a role in reducing hypertension and ICH-related health issues.
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Aging involves tissue and cell potential dysfunction characterized by stem cell senescence and extracellular matrix microenvironment (ECM) alteration. Chondroitin sulfate (CS), found in the ECM of normal cells and tissues, aids in maintaining tissue homeostasis. Here, CS-derived biomaterial (CSDB) from sturgeon is extracted to investigate its antiaging effect in senescence-accelerated mouse prone-8 (SAMP8) mice and elucidate the underlying mechanism of its action.

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Background: Despite the advancement in chemotherapeutic drugs for colon cancer treatment, it is still a life-threatening disease worldwide due to drug resistance. Therefore, an urgently needed to develop novel drugs for colon cancer therapies. AGA is a combination of traditional Chinese medicine Antler's extract (A), Ganoderma lucidum (G), and Antrodia camphorata (A); it contains a lot of biomolecules like polysaccharides, fatty acids, and triterpenoids that are known to exerting anti-oxidative, anti-inflammatory, anti-microbial and anti-tumor activities in oral cancer.

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Complications of diabetes mellitus (DM) range from acute to chronic conditions, leading to multiorgan disorders such as nephropathy, retinopathy, and neuropathy. However, little is known about the influence of DM on intervertebral disc degeneration (IVDD). Moreover, traditional surgical outcomes in DM patients have been found poor, and to date, no definitive alternative treatment exists for DM-induced IVDD.

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Apart from aging process, adult intervertebral disc (IVD) undergoes various degenerative processes. However, the nicotine has not been well identified as a contributing etiology. According to a few studies, nicotine ingestion through smoking, air or clothing may significantly accumulate in active as well as passive smokers.

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Background: Cerebral ischemic events, comprising of excitotoxicity, reactive oxygen production, and inflammation, adversely impact the metabolic-redox circuit in highly active neuronal metabolic profile which maintains energy-dependent brain activities. Therefore, we investigated neuro-regenerative potential of melatonin (Mel), a natural biomaterial secreted by pineal gland.

Methods: We specifically determined whether Mel could influence tunneling nanotubes (TNTs)-mediated transfer of functional mitochondria (Mito) which in turn may alter membrane potential, oxidative stress and apoptotic factors.

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Bony injuries lead to compromised skeletal functional ability which further increase in aging population due to decreased bone mineral density. Therefore, we aimed to investigate the therapeutic potential of platelet-derived biomaterials (PDB) against bone injury. Specifically, we assessed the impact of PDB on osteo-inductive characteristics and migration of mouse embryonic fibroblasts (MEFs).

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Traditional Chinese medicines Antler's extract (A) and (G) and (A) have been known to individually contain a plethora of bioactive factors including triterpenoids, polysaccharides etc., exerting various curative impacts such as anti-inflammatory, anti-oxidative, anti-atherosclerotic and anti-viral activities. However, their combinatorial therapeutic efficacy for oral cancer has not been investigated.

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Recent reports have indicated the role of highly expressed methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) enzyme in cancers, showing poor survival; however, detailed mechanistic insight of metabolic functions of MTHFD2 have not been well-defined. Therefore, we aimed to examine the metabolic functions and cellular reprograming potential of MTHFD2 in lung cancer (LCa). In this study, we initially confirmed the expression levels of MTHFD2 in LCa not only in tissue and Oncomine database, but also at molecular levels.

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Article Synopsis
  • Research indicates that nicotine exposure, beyond inhalation, can occur through air or clothing and may negatively affect health, particularly in passive smokers.
  • In a mouse model of osteoarthritis (OA), nicotine was found to cause cartilage degeneration by suppressing important cellular markers and altering knee joint structure.
  • Treatment with platelet-derived biomaterial (PDB) successfully reduced OA symptoms and restored key signaling pathways related to cartilage health, highlighting its potential in combating nicotine-induced OA progression.
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  • - The text discusses the role of gene expression regulators in cancer, particularly focusing on non-small-cell lung cancer (NSCLC) and how these could be targeted for new therapies
  • - Researchers investigated forkhead box F1 (FOXF1), which was previously identified as important for stemness in lung cancer, by creating NSCLC cell lines that express varying levels of FOXF1
  • - Findings showed that increased FOXF1 expression led to reduced cancer cell growth and migration, primarily by activating the tumor suppressor p21 and causing cell-cycle arrest, suggesting it could be a new strategy for treating lung cancer.
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  • The study investigates the late stages of cerebrorenal syndrome (CRS), where both acute kidney injury (AKI) and ischemic stroke (IS) co-occur, by creating a rat model that simulates this condition.
  • Researchers tested the effects of human platelet-rich plasma (hPRP), a blood-derived material, on various inflammatory markers and pathologic changes in the brain and kidneys post-sham procedure.
  • Results showed that hPRP significantly reduced inflammation and oxidative stress, and improved both cerebro- and reno-protective outcomes, suggesting its potential therapeutic role in CRS.
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Diabetes mellitus (DM) is well-known to exert complications such as retinopathy, cardiomyopathy and neuropathy. However, in recent years, an elevated osteoarthritis (OA) complaints among diabetics have been observed, portending the risk of diabetic OA. Since formation of advanced glycation end products (AGE) is believed to be the etiology of various diseases under hyperglycemic conditions, we firstly established that streptozotocin-induced DM could potentiate the development of OA in C57BL/6J mouse model, and further explored the intra-articularly administered adipose-derived stem cell (ADSC) therapy focusing on underlying AGE-associated mechanism.

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Knee osteoarthritis (OA) is one of the most prevalent disorders in elderly population. Among various therapeutic alternatives, we employed stromal vascular fraction (SVF), a heterogeneous cell population, to regenerate damaged knee cartilage. OA patients were classified on the basis of age, gender, body mass index (BMI), and x-ray-derived Kellgren-Lawrence (KL) grade.

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Article Synopsis
  • - Osteoarthritis (OA) is challenging to treat due to the limited ability of chondrocytes (cartilage cells) to regenerate, and previous research has explored the effects of hyaluronic acid (HA) and platelet-rich plasma (PRP) individually but not together.
  • - In experiments, combining HA and PRP significantly improved chondrocyte survival and growth, while also reducing markers of cell damage and promoting cell cycle progression in OA models.
  • - The combination therapy (HA+PRP) shows potential as a treatment for regenerating articular cartilage in OA, possibly by reducing inflammation and oxidative stress, and inhibiting processes that lead to cartilage breakdown and calcification.
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Article Synopsis
  • Cancer is a major global health issue, and researchers developed a new immunotherapy using mesenchymal stem cells combined with a protein vaccine, but faced limitations with the original method.
  • To improve this approach, they used freshly prepared adipose-derived stem cells (ADSCs) and a modified protein that is non-oncogenic, showing promising results in treating colon and lung cancer in mice.
  • The therapy effectively induced cancer cell death, reduced tumor blood vessel formation, and activated the immune response, suggesting its potential for future clinical applications in cancer treatment.
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Recent years have witnessed an increased prevalence of knee osteoarthritis (KOA) among diabetes mellitus (DM) patients-conditions which might share common risk factors such as obesity and advanced aging. Therefore, we conducted dry-to-wet lab research approaches to assess the correlation of type 1 DM (T1DM) and type 2 DM (T2DM) with KOA among all age and genders of Taiwanese population. The strength of association (odds ratio: OR) was analyzed using a phenome-wide association study portal.

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Background: Few studies have evaluated the risk of oral cavity cancer (OC) in patients with recurrent oral aphthae (ROA) and dry eye syndrome (DES). This study assessed the risk of OC in patients who had received diagnoses of ROA and DES in Taiwan.

Methods: A population-based frequency-matched case-control study was conducted in which data were analyzed from the National Health Insurance Research Database of Taiwan.

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Adipose-derived stromal/stem cells (ASCs) seems to be a promising regenerative therapeutic agent due to the minimally invasive approach of their harvest and multi-lineage differentiation potential. The harvested adipose tissues are further digested to extract stromal vascular fraction (SVF), which is cultured, and the anchorage-dependent cells are isolated in order to characterize their stemness, surface markers, and multi-differentiation potential. The differentiation potential of ASCs is directed through manipulating culture medium composition with an introduction of growth factors to obtain the desired cell type.

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High morbidity and mortality of diabetes mellitus (DM) throughout the human population is a serious threat which needs to be addressed cautiously. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are most prevalent forms. Disruption in insulin regulation and resistance leads to increased formation and accumulation of advanced end products (AGEs), which further enhance oxidative and nitrosative stress leading to microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular complications.

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Article Synopsis
  • The study investigated the link between recurrent aphthous stomatitis (RAS), a common mouth condition, and the risk of developing various cancers using data from Taiwan's National Health Insurance Research Database.
  • Results showed that individuals with RAS had a 30% higher risk of developing cancer compared to those without it, with notable associations for cancers like head and neck, colon, liver, and breast.
  • The findings suggest that patients with RAS, especially men, should be actively screened for certain cancers due to their increased risk.
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