Altered Protein Interactions of the Endogenous Interactome of PTPIP51 towards MAPK Signaling.

Protein-protein interactions play a pivotal role in normal cellular functions as well as in carcinogenesis. The protein-protein interactions form functional clusters during signal transduction. To elucidate the fine calibration of the protein-protein interactions of protein tyrosine phosphatase interacting protein 51 (PTPIP51) a small molecule drug, namely LDC-3, directly targeting PTPIP51 is now available.

How Do Users Map Points Between Dissimilar Shapes?

Finding similar points in globally or locally similar shapes has been studied extensively through the use of various point descriptors or shape-matching methods. However, little work exists on finding similar points in dissimilar shapes. In this paper, we present the results of a study where users were given two dissimilar two-dimensional shapes and asked to map a given point in the first shape to the point in the second shape they consider most similar.

Ballistic superconductivity in semiconductor nanowires.

Semiconductor nanowires have opened new research avenues in quantum transport owing to their confined geometry and electrostatic tunability. They have offered an exceptional testbed for superconductivity, leading to the realization of hybrid systems combining the macroscopic quantum properties of superconductors with the possibility to control charges down to a single electron. These advances brought semiconductor nanowires to the forefront of efforts to realize topological superconductivity and Majorana modes.

Amylin receptor activation in the ventral tegmental area reduces motivated ingestive behavior.

Amylin is produced in the pancreas and the brain, and acts centrally to reduce feeding and body weight. Recent data show that amylin can act in the ventral tegmental area (VTA) to reduce palatable food intake and promote negative energy balance, but the behavioral mechanisms by which these effects occur are not fully understood. The ability of VTA amylin signaling to reduce intake of specific palatable macronutrients (fat or carbohydrate) was tested in rats in several paradigms, including one-bottle acceptance tests, two-bottle choice tests, and a free-choice diet.

[Aseptic loosening of total ankle replacement : One-stage revision ankle arthroplasty].

Objective: To revise one or both loosened prosthesis components, to achieve postoperative pain relief, and preserve ankle range of motion.

Indications: Aseptic loosening of the tibial and/or talar ankle prosthesis components without substantial bone defect of the tibial or talar bone stock.

Contraindications: General surgical or anesthesiological risks, infections, critical soft tissue conditions, nonmanageable hindfoot instability, neurovascular impairment of the lower extremity, neuroarthropathy (e.

RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening.

Aim: To assess serum levels of RANK-ligand (RANKL) and osteoprotegerin (OPG) as biomarkers for periprosthetic joint infection (PJI) and compare their accuracy with standard tests.

Methods: One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics (joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification, patients were categorized into PJI, aseptic loosening, and control groups.

[Aseptic loosening of total ankle replacement and conversion to ankle arthrodesis].

Objective: To remove loosened prosthesis components, to perform augmentation, to address osseous defects, to perform neutrally aligned ankle arthrodesis, and to achieve postoperative pain relief.

Indications: Symptomatic, aseptic loosening of total ankle replacement (TAR) with/without substantial bone defect of the tibial and/or talar bone stock.

Contraindications: General surgical or anesthesiological risks, periprosthetic infection, local or systemic infection, nonmanageable soft tissue problems.

The Effect of Surgical Insertion and Proinflammatory Cytokines on Osteochondral Allograft Survival and Metabolism.

Objective To investigate the responses of refrigerated osteochondral allograft cartilage (OCA) and fresh cartilage (FC), including cell survival and metabolism, to surgical impaction and proinflammatory cytokines. Design Osteochondral plugs (8 mm diameter) were harvested from prolonged-refrigerated (14-28 days) and fresh (≤24 hours postmortem) human femoral hemicondyles and subjected to a 0.2 N s pneumatic impaction impulse.

Directional Limits on Persistent Gravitational Waves from Advanced LIGO's First Observing Run.

We employ gravitational-wave radiometry to map the stochastic gravitational wave background expected from a variety of contributing mechanisms and test the assumption of isotropy using data from the Advanced Laser Interferometer Gravitational Wave Observatory's (aLIGO) first observing run. We also search for persistent gravitational waves from point sources with only minimal assumptions over the 20-1726 Hz frequency band. Finding no evidence of gravitational waves from either point sources or a stochastic background, we set limits at 90% confidence.

Upper Limits on the Stochastic Gravitational-Wave Background from Advanced LIGO's First Observing Run.

A wide variety of astrophysical and cosmological sources are expected to contribute to a stochastic gravitational-wave background. Following the observations of GW150914 and GW151226, the rate and mass of coalescing binary black holes appear to be greater than many previous expectations. As a result, the stochastic background from unresolved compact binary coalescences is expected to be particularly loud.

Dynamic Path Exploration on Mobile Devices.

We present a novel framework for visualizing routes on mobile devices. Our framework is suitable for helping users explore their environment. First, given a starting point and a maximum route length, the system retrieves nearby points of interest (POIs).

Automated Anatomy-Based Tracking of Systemic Arteries in Arbitrary Field-of-View CTA Scans.

We propose an automated pipeline for vessel centerline extraction in 3-D computed tomography angiography (CTA) scans with arbitrary fields of view. The principal steps of the pipeline are body part detection, candidate seed selection, segment tracking, which includes centerline extraction, and vessel tree growing. The final tree-growing step can be instantiated in either a semi- or fully automated fashion.

Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny.

This corrects the article DOI: 10.1038/mp.2017.

CD40-signalling abrogates induction of RORγt Treg cells by intestinal CD103 DCs and causes fatal colitis.

Immune homeostasis in intestinal tissues depends on the generation of regulatory T (Treg) cells. CD103 dendritic cells (DCs) acquire microbiota-derived material from the gut lumen for transport to draining lymph nodes and generation of receptor-related orphan γt (RORγt) Helios-induced Treg (iTreg) cells. Here we show CD40-signalling as a microbe-independent signal that can induce migration of CD103 DCs from the lamina propria (LP) to the mesenteric lymph nodes.

2-D clinorotation alters the uptake of some nutrients in Arabidopsis thaliana.

Future long-term spaceflight missions rely on bioregenerative life support systems (BLSS) in order to provide the required resources for crew survival. Higher plants provide an essential part since they supply food and oxygen and recycle carbon dioxide. There are indications that under space conditions plants might be inefficient regarding the uptake, transport and distribution of nutrients, which in turn affects growth and metabolism.

3D detection of periodic limb movements in sleep.

The standard polysomnographic method for detecting periodic limb movements in sleep (PLMS) includes measuring the electromyography (EMG) signals from electrodes at the left and right tibialis anterior muscles. This procedure has disadvantages as the cabling affects the patients quality of sleep and the electrodes tend to come off during the night, deteriorating data quality. We used contactless monitoring of body movements by a 3D time-of-flight camera mounted above the bed.

Are Instrumented Knee Forces Representative of a Larger Population of Cruciate-Retaining Total Knee Arthroplasties?

Background: It is not known if the loads and motions reported for instrumented knees are generalizable to a larger population of total knee arthroplasty (TKA) patients. The purpose of this study is to (1) report axial implant force data for chair and stair activities for a population of cruciate-retaining TKA patients and (2) compare the population forces to those measured with instrumented TKAs.

Methods: Twenty-three subjects with a cruciate-retaining TKA underwent motion analysis during stair ascending, stair descending, chair sitting, and chair rising activities after informed consent in this institutional review board approved study.

Prediction of Polyethylene Wear Rates from Gait Biomechanics and Implant Positioning in Total Hip Replacement.

Background: Patient-specific gait and surgical variables are known to play an important role in wear of total hip replacements (THR). However a rigorous model, capable of predicting wear rate based on a comprehensive set of subject-specific gait and component-positioning variables, has to our knowledge, not been reported.

Questions/purpose: (1) Are there any differences between patients with high, moderate, and low wear rate in terms of gait and/or positioning variables? (2) Can we design a model to predict the wear rate based on gait and positioning variables? (3) Which group of wear factors (gait or positioning) contributes more to the wear rate?

Patients And Methods: Data on patients undergoing primary unilateral THR who performed a postoperative gait test were screened for inclusion.

Ego depletion in visual perception: Ego-depleted viewers experience less ambiguous figure reversal.

This study examined the effects of ego depletion on ambiguous figure perception. Adults (N = 315) received an ego depletion task and were subsequently tested on their inhibitory control abilities that were indexed by the Stroop task (Experiment 1) and their ability to perceive both interpretations of ambiguous figures that was indexed by reversal (Experiment 2). Ego depletion had a very small effect on reducing inhibitory control (Cohen's d = .

Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny.

Paternal environmental perturbations including exposure to drugs of abuse can produce profound effects on the physiology and behavior of offspring via epigenetic modifications. Here we show that adult drug-naive male offspring of cocaine-exposed sires have memory formation deficits and associated reductions in NMDA receptor-mediated hippocampal synaptic plasticity. Reduced levels of the endogenous NMDA receptor co-agonist d-serine were accompanied by increased expression of the d-serine degrading enzyme d-amino acid oxidase (Dao1) in the hippocampus of cocaine-sired male progeny.

Are developments in mental scanning and mental rotation related?

The development and relation of mental scanning and mental rotation were examined in 4-, 6-, 8-, 10-year old children and adults (N = 102). Based on previous findings from adults and ageing populations, the key question was whether they develop as a set of related abilities and become increasingly differentiated or are unrelated abilities per se. Findings revealed that both mental scanning and rotation abilities develop between 4- and 6 years of age.

Genetic factors underlying boron toxicity tolerance in rice: genome-wide association study and transcriptomic analysis.

Boron (B) toxicity is a nutritional disorder affecting crop production in many parts of the world. This study explored genetic factors associated with B tolerance in rice (Oryza sativa L.) through an integrated genome mapping and transcriptomic approach.