Superficial keratectomy and cryosurgery as therapy for limbal neoplasms in 13 horses.

Objective: To determine the usefulness and clinical outcome of a combined procedure of superficial keratectomy and cryosurgery as a treatment for limbal neoplasms in horses.

Study Design: Retrospective study.

Animals: Thirteen horses with 14 limbal tumors.

Modulation of the cytokine responses in equine macrophages following TACE-inhibition.

The detrimental effects of the pro-inflammatory cytokine TNF-alpha during equine acute abdominal disease are well known. Its pivotal role in many human diseases has led to various in-depth studies regarding its release mechanism, in particular by TNF-alpha converting enzyme (TACE). In this study we investigated the inhibitory effect of a TACE-inhibitor on cytokine release (TNF-alpha, IL-1alpha and IL-6) in three different cell models, including U937 cells, a recently established equine macrophage cell line, known as eCAS, and primary equine PBMC.