Publications by authors named "Wilson de Oliveira Filho"
Clinical outcomes and lung mechanics characteristics between COVID-19 and non-COVID-19-associated acute respiratory distress syndrome: a propensity score analysis of two major randomized trials.
Rev Bras Ter Intensiva
November 2022
Objective: To compare the lung mechanics and outcomes between COVID-19-associated acute respiratory distress syndrome and non-COVID-19-associated acute respiratory distress syndrome.
Methods: We combined data from two randomized trials in acute respiratory distress syndrome, one including only COVID-19 patients and the other including only patients without COVID-19, to determine whether COVID-19-associated acute respiratory distress syndrome is associated with higher 28-day mortality than non-COVID-19 acute respiratory distress syndrome and to examine the differences in lung mechanics between these two types of acute respiratory distress syndrome.
Results: A total of 299 patients with COVID-19-associated acute respiratory distress syndrome and 1,010 patients with non-COVID-19-associated acute respiratory distress syndrome were included in the main analysis.
Article Synopsis
- This study looked at how burn patients in intensive care are helped with breathing machines, specifically using something called lung-protective ventilation.
- Researchers checked the breathing settings of 160 patients from 28 hospitals in 16 countries to see if using low volumes of air helped them recover better.
- They found that most patients were getting this type of ventilation, but it didn't seem to make a big difference in how many days they were off the ventilator or if they were alive 28 days later.
Resuscitation fluid practices in Brazilian intensive care units: a secondary analysis of Fluid-TRIPS.
Rev Bras Ter Intensiva
November 2021
Article Synopsis
- The study examined fluid resuscitation practices in Brazilian intensive care units and compared them to those in 27 other countries as part of the Fluid-TRIPS project.
- On the study day, a significantly lower percentage of patients in Brazil (16.1%) received fluids compared to patients in other countries (26.8%), with a higher emphasis on crystalloids, particularly sodium chloride (0.9%).
- Factors influencing fluid choice included patient serum albumin levels and the type of healthcare provider prescribing the fluids.
Evidence from observational studies suggests that driving pressure is strongly associated with pulmonary injury and mortality, regardless of positive end-expiratory pressure (PEEP) levels, tidal volume, or plateau pressure. Therefore, it is possible that targeting driving pressure may improve the safety of ventilation strategies for patients with acute respiratory distress syndrome (ARDS). However, the clinical effects of a driving pressure-limited strategy for ARDS has not been assessed in randomized controlled trials.
View Article and Find Full Text PDFImportance: The effects of recruitment maneuvers and positive end-expiratory pressure (PEEP) titration on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remain uncertain.
Objective: To determine if lung recruitment associated with PEEP titration according to the best respiratory-system compliance decreases 28-day mortality of patients with moderate to severe ARDS compared with a conventional low-PEEP strategy.
Design, Setting, And Participants: Multicenter, randomized trial conducted at 120 intensive care units (ICUs) from 9 countries from November 17, 2011, through April 25, 2017, enrolling adults with moderate to severe ARDS.