Real-Time Monitoring of Mitochondrial Damage Using Conjugated Oligoelectrolytes.

Conjugated oligoelectrolytes (COEs) comprise a class of fluorescent reporters with tunable optical properties and lipid bilayer affinity. These molecules have proven effective in a range of bioimaging applications; however, their use in characterizing specific subcellular structures remains restricted. Such capabilities would broaden COE applications to understand cellular dysfunction, cell communication, and the targets of different pharmaceutical agents.

Detachment of bovine corneal endothelial cell sheets by cooling-induced surface hydration of poly[()-3-hydroxybutyrate]-based thermoresponsive copolymer coating.

Cell sheet technology (CST) is a fascinating scaffoldless tissue engineering technique to generate a physiologically representative tissue replacement from autologous sources. As compared to conventional enzymatic cell harvesting methods, CST enables the preservation of important cell-to-cell junctions and extracellular matrix (ECM) components. However, covalent grafting methods are often employed for CST.

Facile Construction of a Two-in-One Injectable Micelleplex-Loaded Thermogel System for the Prolonged Delivery of Plasmid DNA.

Nanoparticle-hydrogel systems have recently emerged as a class of interesting hybrid materials with immense potential for several biomedical applications. Remarkably, the incorporation of nanoparticles into a hydrogel may yield synergistic benefits lacking in a singular system. However, most synthetic strategies require laborious steps to achieve the system, severely restricting the process of translational research.

In Situ Synthesis of Magnetic Poly(DMAEAB-co-NIPAm)@FeO Composite Hydrogel for Removal of Dye from Water.

Water pollution by toxic substances, such as dye molecules, remains a major environmental problem that needs to be solved. In the present work, the magnetic composite hydrogel based on the poly(2-(methacryloyloxy)--(2-hydroxyethyl)-,-dimethylethan-1-aminium bromide-co--isopropylacrylamide) copolymer with incorporated FeO particles ((poly(DMAEAB-co-NIPAm)@FeO)) was prepared by an in situ synthesis technique for the efficient removal of dye molecules from water. The successfully synthesized magnetic hydrogel was characterized by FTIR, XRD, TGA, and TEM.