Antidepressant Effect of Sodium Butyrate is Accompanied by Brain Epigenetic Modulation in Rats Subjected to Early or Late Life Stress.

Background: Major depression has a complex and multifactorial etiology constituted by the interaction between genetic and environmental factors in its development.

Objective: The aim of this study was to evaluate the effects of sodium butyrate (SD) on epigenetic enzyme alterations in rats subjected to animal models of depression induced by maternal deprivation (MD) or chronic mild stress (CMS).

Methods: To induce MD, male Wistar rats were deprived of maternal care during the first 10 days of life.