[OLGA, digital platform for the management of national health research networks: An effective model for complex organizations?].

OLGA (which stands for "Activity Management Tool" in French) is a digital management platform developed by F-CRIN, the French Clinical Research Infrastructure Network, which was set up in 2012 to improve the performance and attractiveness of clinical research in France. F-CRIN currently represents a community made up of 21 different components - thematic research, investigation and research networks with a national scope - bringing together the equivalent of 1,500 clinical researchers and 400 research centres all around the country and belonging to many different organizations. Faced with the difficulty of gathering uniform collective data that meet the requirements of F-CRIN's supervisory authorities, in 2015 the F-CRIN community decided to develop a specific monitoring and management tool.

Cholesterol bonded phase as a separation medium in liquid chromatography. Evaluation of properties and applications.

An extensive survey of the properties and separation capabilities of a cholesterol bonded phase is reported. The intermediate hydrophobic/hydrophilic properties of the bonded cholesterol material allows this stationary phase to be used for both reversed-phase and aqueous normal-phase separations. Interesting high selectivity is reported for the structural isomers of some antibiotics.

[Interactions between enterocytes and lymphocytes in the pathogenesis of celiac disease].

MHC antigens are positioned in the centre of the interactions between enterocytes and lymphocytes in the pathogenesis of coeliac disease. This disease is associated with the presence of specific alleles of MHC-class II genes. Class-II-gene products being present also on enterocytic membranes play an important role in the presentation of antigens and might lead in coeliac patients to an extraordinarily effective stimulation of CD4+ and/or CD8+ cells which induce damage to the intestinal epithelium by various mechanisms.

Changes of ATPase activities in erythrocytes of rats with hypothalamic obesity.

Na,K- and Ca,Mg-ATPase activities in the membrane of red blood cells (RBC) were determined in glutamate treated obese rats (GOR). Both activities are related oppositely. In the obese rats the Na,K-ATPase is higher but the efficiency in maintenance of Na/K-ion concentration gradients is diminished.

[Glucose utilization in adipose tissue of rats in chronic somatotropin deficiency].

Injections of monosodium glutamate to neonate rats induce chronic growth hormone deficiency by hypothalamic lesions in the regions of the nucleus arcuatus and the eminentia mediana. The glutamate treated rats develop massive obesity. By this type of obesity hyperinsulinemia in the dynamic phase is not evident.

Development of hypothalamic obesity in growing rats.

Administration of monosodium glutamate to neonate rats causes hypothalamic lesions in the region of the nucleus arcuatus and the eminentia mediana, followed by massive accumulation of triglycerides, diminished secretion of growth hormone, reduced body length and organ weights and diminished number of adipocytes (hypoplastic-hypertrophic obesity). Locomotor activity of obese animals is reduced by about 50%. Food intake is increased by about 10% during growth and development of obesity but decreased beneath the level of that in control animals in the stationary phase of obesity.