Publications by authors named "Wilma Fick"
The availability of genome sequencing data in combination with knowledge of expressed genes via transcriptome and proteome data has greatly advanced our understanding of arthropod vectors of disease. Not only have we gained insight into vector biology, but also into their respective vector-pathogen interactions. By combining the strengths of postgenomic databases and reverse genetic approaches such as RNAi, the numbers of available drug and vaccine targets, as well as number of transgenes for subsequent transgenic or paratransgenic approaches, have expanded.
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- The study explores using soluble chimeric trimers of the VP7 protein from African horse sickness virus as a vaccine delivery method by inserting foreign peptides into its structure.
- Key modifications to the VP7 gene were made, resulting in several soluble fusion proteins that can still form effective trimers and maintain their immunological function.
- Results showed that these modified proteins successfully triggered a specific immune response in guinea pigs, with the addition of l-Arginine helping to enhance solubility and purity of the proteins.