Publications by authors named "Willy Lutz"
Article Synopsis
- - SARS-CoV-2 infection can cause both immediate and long-lasting neurological issues, complicating the understanding of the virus's impact on the brain after COVID-19.
- - Research using brain models and samples shows that while SARS-CoV-2 can infect neural cells, the extent is low, but it can lead to abnormal changes in synapses and electrical activity in the brain.
- - The study found that treating brain organoids with a specific compound could help restore normal brain activity and reduce the negative effects caused by the virus at synapses, highlighting potential avenues for understanding and treating COVID-19-related brain complications.
Viral neuroinfections represent a major health burden for which the development of antivirals is needed. Antiviral compounds that target the consequences of a brain infection (symptomatic treatment) rather than the cause (direct-acting antivirals) constitute a promising mitigation strategy that requires to be investigated in relevant models. However, physiological surrogates mimicking an adult human cortex are lacking, limiting our understanding of the mechanisms associated with viro-induced neurological disorders.
View Article and Find Full Text PDFHaemophilic knee arthropathy: long-term outcome after total knee replacement.
Knee Surg Sports Traumatol Arthrosc
December 2012
Purpose: The objective of this study was to evaluate the long-term outcome and prosthetic survival of primary total knee arthroplasty in haemophilic patients. It was hypothesized that the infection and revision rate are higher and the outcome inferior when compared with patients without haemophilia.
Methods: Between 1985 and 2004, forty-three consecutive primary total knee replacements were performed in thirty haemophilic patients.