Signet ring cells in esophageal and gastroesophageal junction carcinomas have a more aggressive biological behavior.

Objective: To clarify the biologic behavior of esophageal signet ring cell (SRC) carcinomas of the esophagus and gastroesophageal junction (GEJ). To evaluate the accuracy of pretreatment biopsies in diagnosing true SRC carcinoma.

Background: In contrast with gastric cancer, little is known about the biologic behavior and prognosis of SRC.