Pnictogen-Assisted Self-Assembly as a Means to Study Mediated Thiol/Disulfide Exchange in Supramolecular Dynamic Covalent Assemblies.

Thiol-disulfide interchange has been a large field of study for both biochemists and physical organic chemists alike due to its prevalence within biological systems and fundamentally interesting dynamic nature. More recently, efforts have been made to harness the power of this reversible reaction to make self-assembling systems of macrocyclic molecules. However, less effort has focused on the fundamental work of isolating these assemblies and studying the factors that control the assembly and sorting of these emerging cyclic systems.

Benchmarking the placement of hydrosulfide in the Hofmeister series using a bambus[6]uril-based ChemFET sensor.

Hydrosulfide (HS) is the conjugate base of gasotransmitter hydrogen sulfide (HS) and is a physiologically-relevant small molecule of great interest in the anion sensing community. However, selective sensing and molecular recognition of HS in water remains difficult because, in addition to the diffuse charge and high solvation energy of anions, HS is highly nucleophilic and readily oxidizes into other reactive sulfur species. Moreover, the direct placement of HS in the Hofmeister series remains unclear.