Publications by authors named "Willian Ayala Correa"
Article Synopsis
- * The study revealed that cyclophosphamide alone increases genomic damage and decreases phagocytosis in Swiss male mice, but combining it with the resorcinolic lipid reduces genomic damage by up to 33.8%.
- * Molecular docking shows the resorcinolic lipid binds more strongly to DNA than cyclophosphamide's active metabolite, indicating its potential as both a therapeutic candidate and a chemotherapeutic adjuvant.
3-Heptylidene-4,6-Dimethoxy-3-Isobenzofuran-1-One Is Genotoxic, Increases the Frequency of Cell Death, and Potentiates the Effects of Cyclophosphamide and Cisplatin.
Silvia Cordeiro das Neves Flavio Henrique de Araújo Willian Ayala Correa Allana Cristina Faustino Martins Henrique Rodrigues Scherer Coelho
Molecules
January 2023
3-heptylidene-4,6-dimethoxy-3-isobenzofuran-1-one (Phthalide ) is the precursor of three resorcinol lipids that have been described as potential chemotherapeutic agents and capable of potentiating the effects of cyclophosphamide. In this study, we evaluated the genotoxic potential, cell-killing potential, and interactions with cyclophosphamide and cisplatin of phthalide . Twelve groups were created from 120 mice: Negative Control, cyclophosphamide (100 mg/kg), cisplatin (6 mg/kg), Phthalide (5, 10 and 20 mg/kg), and associations of with cyclophosphamide and with cisplatin.
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